Genomic Landscape of Pleural Mesothelioma and Therapeutic Aftermaths

Alistair Nash, Jenette Creaney

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: In this article, we provide a comprehensive analysis of recent progress in the genetic characterisation of pleural mesothelioma, and the translation of these findings to clinical practice. Recent Findings: Advancements in sequencing technology have allowed the identification of driver mutations and improved our understanding of how these mutations may shape the mesothelioma tumour microenvironment. However, the identification of frequently mutated regions including CDKN2A, BAP1 and NF2 have, to date, not yet yielded targeted therapy options that outperform standard chemo- and immunotherapies. Similarly, the association between mutational profile and the immune microenvironment or immunotherapy response is not well characterised. Summary: Further research into the link between tumour mutational profile and response to therapy is critical for identifying targetable vulnerabilities and stratifying patients for therapy.

Original languageEnglish
Pages (from-to)1515-1522
Number of pages8
JournalCurrent Oncology Reports
Issue number12
Early online date28 Nov 2023
Publication statusPublished - Dec 2023


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