Genomic impacts of transposable elements in Arabidopsis

Timothy James Stuart

doi:10.4225/23/5ae146dda7fe9

Genomic impacts of transposable elements in Arabidopsis

Timothy James Stuart

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Transposable elements (TEs) are self-replicating mobile genetic elements. Epigenetic silencing mechanisms have evolved that combat the over-replication of TE sequences. As TEs have complex impacts on the host genome, several gaps exist in our current understanding of TE biology which I aim to address in this thesis. I explore role of TEs in shaping epigenomic and transcriptional landscapes between individual plants in a population, between cell types in a single individual, and between individual cells in the plant root. Together, this work exposes the evolutionary, epigenetic, and regulatory impacts of TEs on the genome.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Lister, Ryan, Supervisor Millar, Harvey, Supervisor Small, Ian, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	22 Mar 2018
DOIs	https://doi.org/10.4225/23/5ae146dda7fe9
Publication status	Unpublished - 2018

Embargo information

Embargoed from 28/06/2018 to 28/12/2019. Made publicly available on 28/12/2019.

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10.4225/23/5ae146dda7fe9

THESIS - DOCTOR OF PHILOSOPHY - STUART Timothy James - 2018
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Cite this

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abstract = "Transposable elements (TEs) are self-replicating mobile genetic elements. Epigenetic silencing mechanisms have evolved that combat the over-replication of TE sequences. As TEs have complex impacts on the host genome, several gaps exist in our current understanding of TE biology which I aim to address in this thesis. I explore role of TEs in shaping epigenomic and transcriptional landscapes between individual plants in a population, between cell types in a single individual, and between individual cells in the plant root. Together, this work exposes the evolutionary, epigenetic, and regulatory impacts of TEs on the genome. ",

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AB - Transposable elements (TEs) are self-replicating mobile genetic elements. Epigenetic silencing mechanisms have evolved that combat the over-replication of TE sequences. As TEs have complex impacts on the host genome, several gaps exist in our current understanding of TE biology which I aim to address in this thesis. I explore role of TEs in shaping epigenomic and transcriptional landscapes between individual plants in a population, between cell types in a single individual, and between individual cells in the plant root. Together, this work exposes the evolutionary, epigenetic, and regulatory impacts of TEs on the genome.

KW - DNA methylation

KW - Transposable element

KW - Arabidopsis

KW - Single cell

KW - Genomics

KW - Bioinformatics

U2 - 10.4225/23/5ae146dda7fe9

DO - 10.4225/23/5ae146dda7fe9

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Genomic impacts of transposable elements in Arabidopsis

Abstract

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