Genomic analyses of cancer susceptibility genes

Xiaoshun Shi

Research output: ThesisDoctoral Thesis

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Abstract

Cancer Susceptibility genes (CSGs) are genes in which inherited variants increase the risk of cancer. This project characterizes CSGs at many levels, ranging from the discovery of genes specifically affecting lung cancer in men; to a genome-wide study of how a novel class of DNA modification (6mA) affects lung cancer; to population differences in CSG variants in a wide range of cancers; to evaluation of expression of every human gene in many tissues in all cancers. The research provides insight into how CSGs affect cancer risk and reveals potential targets for precision oncology and cancer prevention.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Morahan, Grant, Supervisor
  • Young, Sylvia, Supervisor
Award date14 Oct 2022
DOIs
Publication statusUnpublished - 2022

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