Genomic analyses of cancer susceptibility genes

Xiaoshun Shi

doi:10.26182/vcpj-rx96

Genomic analyses of cancer susceptibility genes

Xiaoshun Shi

Research output: Thesis › Doctoral Thesis

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Abstract

Cancer Susceptibility genes (CSGs) are genes in which inherited variants increase the risk of cancer. This project characterizes CSGs at many levels, ranging from the discovery of genes specifically affecting lung cancer in men; to a genome-wide study of how a novel class of DNA modification (6mA) affects lung cancer; to population differences in CSG variants in a wide range of cancers; to evaluation of expression of every human gene in many tissues in all cancers. The research provides insight into how CSGs affect cancer risk and reveals potential targets for precision oncology and cancer prevention.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Morahan, Grant, Supervisor Young, Sylvia, Supervisor
Award date	14 Oct 2022
DOIs	https://doi.org/10.26182/vcpj-rx96
Publication status	Unpublished - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/vcpj-rx96

THESIS - DOCTOR OF PHILOSOPHY - SHI Xiaoshun - 2022
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2 Article

Identification of genetic variants associated with sex-specific lung-cancer risk
Shi, X., Young, S. & Morahan, G., 1 Dec 2021, In: Cancers. 13, 24, 6379.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Citations (Scopus)
The first comprehensive database of germline pathogenic variants in East Asian cancer patients
Shi, X., Li, R., Zhai, J., Chen, A. M., Huang, K., Zheng, Z., Chen, Z., Dong, X., Liu, X., Lu, D., Feng, S., Diao, D., Ren, P., Liu, Z., Morahan, G. & Cai, K., 29 Dec 2021, In: Database : the journal of biological databases and curation. 2021, 2021, baab075.
Research output: Contribution to journal › Article › peer-review

Open Access

Cite this

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title = "Genomic analyses of cancer susceptibility genes",

abstract = "Cancer Susceptibility genes (CSGs) are genes in which inherited variants increase the risk of cancer. This project characterizes CSGs at many levels, ranging from the discovery of genes specifically affecting lung cancer in men; to a genome-wide study of how a novel class of DNA modification (6mA) affects lung cancer; to population differences in CSG variants in a wide range of cancers; to evaluation of expression of every human gene in many tissues in all cancers. The research provides insight into how CSGs affect cancer risk and reveals potential targets for precision oncology and cancer prevention.",

keywords = "cancer susceptibility genes, cancer risk, SNP, germline variants, cell autonomy, DNA 6mA methylation, lung cancer, precision medicine",

author = "Xiaoshun Shi",

year = "2022",

doi = "10.26182/vcpj-rx96",

language = "English",

school = "The University of Western Australia",

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AU - Shi, Xiaoshun

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N2 - Cancer Susceptibility genes (CSGs) are genes in which inherited variants increase the risk of cancer. This project characterizes CSGs at many levels, ranging from the discovery of genes specifically affecting lung cancer in men; to a genome-wide study of how a novel class of DNA modification (6mA) affects lung cancer; to population differences in CSG variants in a wide range of cancers; to evaluation of expression of every human gene in many tissues in all cancers. The research provides insight into how CSGs affect cancer risk and reveals potential targets for precision oncology and cancer prevention.

AB - Cancer Susceptibility genes (CSGs) are genes in which inherited variants increase the risk of cancer. This project characterizes CSGs at many levels, ranging from the discovery of genes specifically affecting lung cancer in men; to a genome-wide study of how a novel class of DNA modification (6mA) affects lung cancer; to population differences in CSG variants in a wide range of cancers; to evaluation of expression of every human gene in many tissues in all cancers. The research provides insight into how CSGs affect cancer risk and reveals potential targets for precision oncology and cancer prevention.

KW - cancer susceptibility genes

KW - cancer risk

KW - SNP

KW - germline variants

KW - cell autonomy

KW - DNA 6mA methylation

KW - lung cancer

KW - precision medicine

U2 - 10.26182/vcpj-rx96

DO - 10.26182/vcpj-rx96

M3 - Doctoral Thesis

ER -

Genomic analyses of cancer susceptibility genes

Abstract

UN SDGs

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Research output

Identification of genetic variants associated with sex-specific lung-cancer risk

The first comprehensive database of germline pathogenic variants in East Asian cancer patients

Cite this