Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

K. Estrada; U. Styrkarsdottir; E. Evangelou; Y.-H. Hsu; E.L. Duncan; E.E. Ntzani; L. Oei; O.M.E. Albagha; N. Amin; J.P. Kemp; D.L. Koller; G. Li; C.-T. Liu; R.L. Minster; A. Moayyeri; L. Vandenput; D. Willner; S.-M. Xiao; L.M. Yerges-Armstrong; H.-F. Zheng; N. Alonso; J. Eriksson; C.M. Kammerer; S.K. Kaptoge; P.J. Leo; G. Thorleifsson; Scott Wilson; J.F. Wilson; V. Aalto; M. Alen; A.K. Aragaki; T. Aspelund; J.R. Center; Z. Dailiana; D.J. Duggan; M. Garcia; N. Garcia-Giralt; S. Giroux; G. Hallmans; L.J. Hocking; L.B. Husted; K.A. Jameson; R. Khusainova; G.S. Kim; C. Kooperberg; T. Koromila; M. Kruk; M. Laaksonen; A.Z. Lacroix; S.H. Lee; P.C. Leung; Joshua Lewis; L. Masi; S. Mencej-Bedrac; T.V. Nguyen; X. Nogues; M.S. Patel; J. Prezelj; L.M. Rose; S. Scollen; K. Siggeirsdottir; A.V. Smith; O. Svensson; S. Trompet; O. Trummer; N.M. Van Schoor; J. Woo; Kun Zhu; S. Balcells; M.L. Brandi; B.M. Buckley; S. Cheng; C. Christiansen; C. Cooper; G. Dedoussis; I. Ford; M. Frost; D. Goltzman; J. González-Macías; M. Kähönen; M. Karlsson; E. Khusnutdinova; J.-M. Koh; P. Kollia; B.L. Langdahl; W.D. Leslie; P. Lips; O. Ljunggren; R.S. Lorenc; J. Marc; D. Mellström; B. Obermayer-Pietsch; J.M. Olmos; U. Pettersson-Kymmer; D.M. Reid; J.A. Riancho; P.M. Ridker; F. Rousseau; P.E.S. Lagboom; N.L.S. Tang; R. Urreizti; W. Van Hul; J. Viikari; M.T. Zarrabeitia; Y.S. Aulchenko; M. Castano-Betancourt; E. Grundberg; L. Herrera; T. Ingvarsson; H. Johannsdottir; T. Kwan; R. Li; R. Luben; C. Medina-Gómez; S. Th Palsson; S. Reppe; J.I. Rotter; G. Sigurdsson; J.B.J. Van Meurs; D. Verlaan; F.M.K. Williams; A.R. Wood; Y. Zhou; K.M. Gautvik; T. Pastinen; S. Raychaudhuri; J.A. Cauley; D.I. Chasman; G.R. Clark; S.R. Cummings; P. Danoy; E.M. Dennison; R. Eastell; J.A. Eisman; V. Gudnason; A. Hofman; R.D. Jackson; G. Jones; J.W. Jukema; K.-T. Khaw; T. Lehtimäki; Y. Liu; M. Lorentzon; E. Mccloskey; B.D. Mitchell; K. Nandakumar; G.C. Nicholson; B.A. Oostra; M. Peacock; H.A.P. Pols; Richard Prince; O. Raitakari; I.R. Reid; J. Robbins; P.N. Sambrook; P.C. Sham; A.R. Shuldiner; F.A. Tylavsky; C.M. Van Duijn; N.J. Wareham; L.A. Cupples; M.J. Econs; D.M. Evans; T.B. Harris; A.W.C. Kung; B.M. Psaty; J. Reeve; T.D. Spector; E.A. Streeten; M.C. Zillikens; U. Thorsteinsdottir; C. Ohlsson; D. Karasik; J.B. Richards; M.A. Brown; K. Stefansson; A.G. Uitterlinden; S.H. Ralston; J.P.A. Ioannidis; D.P. Kiel; F. Rivadeneira

doi:10.1038/ng.2249

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

K. Estrada, U. Styrkarsdottir, E. Evangelou, Y.-H. Hsu, E.L. Duncan, E.E. Ntzani, L. Oei, O.M.E. Albagha, N. Amin, J.P. Kemp, D.L. Koller, G. Li, C.-T. Liu, R.L. Minster, A. Moayyeri, L. Vandenput, D. Willner, S.-M. Xiao, L.M. Yerges-Armstrong, H.-F. ZhengN. Alonso, J. Eriksson, C.M. Kammerer, S.K. Kaptoge, P.J. Leo, G. Thorleifsson, Scott Wilson, J.F. Wilson, V. Aalto, M. Alen, A.K. Aragaki, T. Aspelund, J.R. Center, Z. Dailiana, D.J. Duggan, M. Garcia, N. Garcia-Giralt, S. Giroux, G. Hallmans, L.J. Hocking, L.B. Husted, K.A. Jameson, R. Khusainova, G.S. Kim, C. Kooperberg, T. Koromila, M. Kruk, M. Laaksonen, A.Z. Lacroix, S.H. Lee, P.C. Leung, Joshua Lewis, L. Masi, S. Mencej-Bedrac, T.V. Nguyen, X. Nogues, M.S. Patel, J. Prezelj, L.M. Rose, S. Scollen, K. Siggeirsdottir, A.V. Smith, O. Svensson, S. Trompet, O. Trummer, N.M. Van Schoor, J. Woo, Kun Zhu, S. Balcells, M.L. Brandi, B.M. Buckley, S. Cheng, C. Christiansen, C. Cooper, G. Dedoussis, I. Ford, M. Frost, D. Goltzman, J. González-Macías, M. Kähönen, M. Karlsson, E. Khusnutdinova, J.-M. Koh, P. Kollia, B.L. Langdahl, W.D. Leslie, P. Lips, O. Ljunggren, R.S. Lorenc, J. Marc, D. Mellström, B. Obermayer-Pietsch, J.M. Olmos, U. Pettersson-Kymmer, D.M. Reid, J.A. Riancho, P.M. Ridker, F. Rousseau, P.E.S. Lagboom, N.L.S. Tang, R. Urreizti, W. Van Hul, J. Viikari, M.T. Zarrabeitia, Y.S. Aulchenko, M. Castano-Betancourt, E. Grundberg, L. Herrera, T. Ingvarsson, H. Johannsdottir, T. Kwan, R. Li, R. Luben, C. Medina-Gómez, S. Th Palsson, S. Reppe, J.I. Rotter, G. Sigurdsson, J.B.J. Van Meurs, D. Verlaan, F.M.K. Williams, A.R. Wood, Y. Zhou, K.M. Gautvik, T. Pastinen, S. Raychaudhuri, J.A. Cauley, D.I. Chasman, G.R. Clark, S.R. Cummings, P. Danoy, E.M. Dennison, R. Eastell, J.A. Eisman, V. Gudnason, A. Hofman, R.D. Jackson, G. Jones, J.W. Jukema, K.-T. Khaw, T. Lehtimäki, Y. Liu, M. Lorentzon, E. Mccloskey, B.D. Mitchell, K. Nandakumar, G.C. Nicholson, B.A. Oostra, M. Peacock, H.A.P. Pols, Richard Prince, O. Raitakari, I.R. Reid, J. Robbins, P.N. Sambrook, P.C. Sham, A.R. Shuldiner, F.A. Tylavsky, C.M. Van Duijn, N.J. Wareham, L.A. Cupples, M.J. Econs, D.M. Evans, T.B. Harris, A.W.C. Kung, B.M. Psaty, J. Reeve, T.D. Spector, E.A. Streeten, M.C. Zillikens, U. Thorsteinsdottir, C. Ohlsson, D. Karasik, J.B. Richards, M.A. Brown, K. Stefansson, A.G. Uitterlinden, S.H. Ralston, J.P.A. Ioannidis, D.P. Kiel, F. Rivadeneira

Research output: Contribution to journal › Article › peer-review

955 Citations (Scopus)

Original language	English
Pages (from-to)	491-503
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2249
Publication status	Published - 2012

Access to Document

10.1038/ng.2249

Cite this

Estrada, K., Styrkarsdottir, U., Evangelou, E., Hsu, Y.-H., Duncan, E. L., Ntzani, E. E., Oei, L., Albagha, O. M. E., Amin, N., Kemp, J. P., Koller, D. L., Li, G., Liu, C.-T., Minster, R. L., Moayyeri, A., Vandenput, L., Willner, D., Xiao, S.-M., Yerges-Armstrong, L. M., ... Rivadeneira, F. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491-503. https://doi.org/10.1038/ng.2249

@article{ad4f86e836924de291a8906dadd06416,

title = "Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture",

author = "K. Estrada and U. Styrkarsdottir and E. Evangelou and Y.-H. Hsu and E.L. Duncan and E.E. Ntzani and L. Oei and O.M.E. Albagha and N. Amin and J.P. Kemp and D.L. Koller and G. Li and C.-T. Liu and R.L. Minster and A. Moayyeri and L. Vandenput and D. Willner and S.-M. Xiao and L.M. Yerges-Armstrong and H.-F. Zheng and N. Alonso and J. Eriksson and C.M. Kammerer and S.K. Kaptoge and P.J. Leo and G. Thorleifsson and Scott Wilson and J.F. Wilson and V. Aalto and M. Alen and A.K. Aragaki and T. Aspelund and J.R. Center and Z. Dailiana and D.J. Duggan and M. Garcia and N. Garcia-Giralt and S. Giroux and G. Hallmans and L.J. Hocking and L.B. Husted and K.A. Jameson and R. Khusainova and G.S. Kim and C. Kooperberg and T. Koromila and M. Kruk and M. Laaksonen and A.Z. Lacroix and S.H. Lee and P.C. Leung and Joshua Lewis and L. Masi and S. Mencej-Bedrac and T.V. Nguyen and X. Nogues and M.S. Patel and J. Prezelj and L.M. Rose and S. Scollen and K. Siggeirsdottir and A.V. Smith and O. Svensson and S. Trompet and O. Trummer and {Van Schoor}, N.M. and J. Woo and Kun Zhu and S. Balcells and M.L. Brandi and B.M. Buckley and S. Cheng and C. Christiansen and C. Cooper and G. Dedoussis and I. Ford and M. Frost and D. Goltzman and J. Gonz{\'a}lez-Mac{\'i}as and M. K{\"a}h{\"o}nen and M. Karlsson and E. Khusnutdinova and J.-M. Koh and P. Kollia and B.L. Langdahl and W.D. Leslie and P. Lips and O. Ljunggren and R.S. Lorenc and J. Marc and D. Mellstr{\"o}m and B. Obermayer-Pietsch and J.M. Olmos and U. Pettersson-Kymmer and D.M. Reid and J.A. Riancho and P.M. Ridker and F. Rousseau and P.E.S. Lagboom and N.L.S. Tang and R. Urreizti and {Van Hul}, W. and J. Viikari and M.T. Zarrabeitia and Y.S. Aulchenko and M. Castano-Betancourt and E. Grundberg and L. Herrera and T. Ingvarsson and H. Johannsdottir and T. Kwan and R. Li and R. Luben and C. Medina-G{\'o}mez and {Th Palsson}, S. and S. Reppe and J.I. Rotter and G. Sigurdsson and {Van Meurs}, J.B.J. and D. Verlaan and F.M.K. Williams and A.R. Wood and Y. Zhou and K.M. Gautvik and T. Pastinen and S. Raychaudhuri and J.A. Cauley and D.I. Chasman and G.R. Clark and S.R. Cummings and P. Danoy and E.M. Dennison and R. Eastell and J.A. Eisman and V. Gudnason and A. Hofman and R.D. Jackson and G. Jones and J.W. Jukema and K.-T. Khaw and T. Lehtim{\"a}ki and Y. Liu and M. Lorentzon and E. Mccloskey and B.D. Mitchell and K. Nandakumar and G.C. Nicholson and B.A. Oostra and M. Peacock and H.A.P. Pols and Richard Prince and O. Raitakari and I.R. Reid and J. Robbins and P.N. Sambrook and P.C. Sham and A.R. Shuldiner and F.A. Tylavsky and {Van Duijn}, C.M. and N.J. Wareham and L.A. Cupples and M.J. Econs and D.M. Evans and T.B. Harris and A.W.C. Kung and B.M. Psaty and J. Reeve and T.D. Spector and E.A. Streeten and M.C. Zillikens and U. Thorsteinsdottir and C. Ohlsson and D. Karasik and J.B. Richards and M.A. Brown and K. Stefansson and A.G. Uitterlinden and S.H. Ralston and J.P.A. Ioannidis and D.P. Kiel and F. Rivadeneira",

year = "2012",

doi = "10.1038/ng.2249",

language = "English",

volume = "44",

pages = "491--503",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group - Macmillan Publishers",

number = "5",

}

Estrada, K, Styrkarsdottir, U, Evangelou, E, Hsu, Y-H, Duncan, EL, Ntzani, EE, Oei, L, Albagha, OME, Amin, N, Kemp, JP, Koller, DL, Li, G, Liu, C-T, Minster, RL, Moayyeri, A, Vandenput, L, Willner, D, Xiao, S-M, Yerges-Armstrong, LM, Zheng, H-F, Alonso, N, Eriksson, J, Kammerer, CM, Kaptoge, SK, Leo, PJ, Thorleifsson, G, Wilson, S, Wilson, JF, Aalto, V, Alen, M, Aragaki, AK, Aspelund, T, Center, JR, Dailiana, Z, Duggan, DJ, Garcia, M, Garcia-Giralt, N, Giroux, S, Hallmans, G, Hocking, LJ, Husted, LB, Jameson, KA, Khusainova, R, Kim, GS, Kooperberg, C, Koromila, T, Kruk, M, Laaksonen, M, Lacroix, AZ, Lee, SH, Leung, PC, Lewis, J, Masi, L, Mencej-Bedrac, S, Nguyen, TV, Nogues, X, Patel, MS, Prezelj, J, Rose, LM, Scollen, S, Siggeirsdottir, K, Smith, AV, Svensson, O, Trompet, S, Trummer, O, Van Schoor, NM, Woo, J, Zhu, K, Balcells, S, Brandi, ML, Buckley, BM, Cheng, S, Christiansen, C, Cooper, C, Dedoussis, G, Ford, I, Frost, M, Goltzman, D, González-Macías, J, Kähönen, M, Karlsson, M, Khusnutdinova, E, Koh, J-M, Kollia, P, Langdahl, BL, Leslie, WD, Lips, P, Ljunggren, O, Lorenc, RS, Marc, J, Mellström, D, Obermayer-Pietsch, B, Olmos, JM, Pettersson-Kymmer, U, Reid, DM, Riancho, JA, Ridker, PM, Rousseau, F, Lagboom, PES, Tang, NLS, Urreizti, R, Van Hul, W, Viikari, J, Zarrabeitia, MT, Aulchenko, YS, Castano-Betancourt, M, Grundberg, E, Herrera, L, Ingvarsson, T, Johannsdottir, H, Kwan, T, Li, R, Luben, R, Medina-Gómez, C, Th Palsson, S, Reppe, S, Rotter, JI, Sigurdsson, G, Van Meurs, JBJ, Verlaan, D, Williams, FMK, Wood, AR, Zhou, Y, Gautvik, KM, Pastinen, T, Raychaudhuri, S, Cauley, JA, Chasman, DI, Clark, GR, Cummings, SR, Danoy, P, Dennison, EM, Eastell, R, Eisman, JA, Gudnason, V, Hofman, A, Jackson, RD, Jones, G, Jukema, JW, Khaw, K-T, Lehtimäki, T, Liu, Y, Lorentzon, M, Mccloskey, E, Mitchell, BD, Nandakumar, K, Nicholson, GC, Oostra, BA, Peacock, M, Pols, HAP, Prince, R, Raitakari, O, Reid, IR, Robbins, J, Sambrook, PN, Sham, PC, Shuldiner, AR, Tylavsky, FA, Van Duijn, CM, Wareham, NJ, Cupples, LA, Econs, MJ, Evans, DM, Harris, TB, Kung, AWC, Psaty, BM, Reeve, J, Spector, TD, Streeten, EA, Zillikens, MC, Thorsteinsdottir, U, Ohlsson, C, Karasik, D, Richards, JB, Brown, MA, Stefansson, K, Uitterlinden, AG, Ralston, SH, Ioannidis, JPA, Kiel, DP & Rivadeneira, F 2012, 'Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture', Nature Genetics, vol. 44, no. 5, pp. 491-503. https://doi.org/10.1038/ng.2249

TY - JOUR

T1 - Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

AU - Estrada, K.

AU - Styrkarsdottir, U.

AU - Evangelou, E.

AU - Hsu, Y.-H.

AU - Duncan, E.L.

AU - Ntzani, E.E.

AU - Oei, L.

AU - Albagha, O.M.E.

AU - Amin, N.

AU - Kemp, J.P.

AU - Koller, D.L.

AU - Li, G.

AU - Liu, C.-T.

AU - Minster, R.L.

AU - Moayyeri, A.

AU - Vandenput, L.

AU - Willner, D.

AU - Xiao, S.-M.

AU - Yerges-Armstrong, L.M.

AU - Zheng, H.-F.

AU - Alonso, N.

AU - Eriksson, J.

AU - Kammerer, C.M.

AU - Kaptoge, S.K.

AU - Leo, P.J.

AU - Thorleifsson, G.

AU - Wilson, Scott

AU - Wilson, J.F.

AU - Aalto, V.

AU - Alen, M.

AU - Aragaki, A.K.

AU - Aspelund, T.

AU - Center, J.R.

AU - Dailiana, Z.

AU - Duggan, D.J.

AU - Garcia, M.

AU - Garcia-Giralt, N.

AU - Giroux, S.

AU - Hallmans, G.

AU - Hocking, L.J.

AU - Husted, L.B.

AU - Jameson, K.A.

AU - Khusainova, R.

AU - Kim, G.S.

AU - Kooperberg, C.

AU - Koromila, T.

AU - Kruk, M.

AU - Laaksonen, M.

AU - Lacroix, A.Z.

AU - Lee, S.H.

AU - Leung, P.C.

AU - Lewis, Joshua

AU - Masi, L.

AU - Mencej-Bedrac, S.

AU - Nguyen, T.V.

AU - Nogues, X.

AU - Patel, M.S.

AU - Prezelj, J.

AU - Rose, L.M.

AU - Scollen, S.

AU - Siggeirsdottir, K.

AU - Smith, A.V.

AU - Svensson, O.

AU - Trompet, S.

AU - Trummer, O.

AU - Van Schoor, N.M.

AU - Woo, J.

AU - Zhu, Kun

AU - Balcells, S.

AU - Brandi, M.L.

AU - Buckley, B.M.

AU - Cheng, S.

AU - Christiansen, C.

AU - Cooper, C.

AU - Dedoussis, G.

AU - Ford, I.

AU - Frost, M.

AU - Goltzman, D.

AU - González-Macías, J.

AU - Kähönen, M.

AU - Karlsson, M.

AU - Khusnutdinova, E.

AU - Koh, J.-M.

AU - Kollia, P.

AU - Langdahl, B.L.

AU - Leslie, W.D.

AU - Lips, P.

AU - Ljunggren, O.

AU - Lorenc, R.S.

AU - Marc, J.

AU - Mellström, D.

AU - Obermayer-Pietsch, B.

AU - Olmos, J.M.

AU - Pettersson-Kymmer, U.

AU - Reid, D.M.

AU - Riancho, J.A.

AU - Ridker, P.M.

AU - Rousseau, F.

AU - Lagboom, P.E.S.

AU - Tang, N.L.S.

AU - Urreizti, R.

AU - Van Hul, W.

AU - Viikari, J.

AU - Zarrabeitia, M.T.

AU - Aulchenko, Y.S.

AU - Castano-Betancourt, M.

AU - Grundberg, E.

AU - Herrera, L.

AU - Ingvarsson, T.

AU - Johannsdottir, H.

AU - Kwan, T.

AU - Li, R.

AU - Luben, R.

AU - Medina-Gómez, C.

AU - Th Palsson, S.

AU - Reppe, S.

AU - Rotter, J.I.

AU - Sigurdsson, G.

AU - Van Meurs, J.B.J.

AU - Verlaan, D.

AU - Williams, F.M.K.

AU - Wood, A.R.

AU - Zhou, Y.

AU - Gautvik, K.M.

AU - Pastinen, T.

AU - Raychaudhuri, S.

AU - Cauley, J.A.

AU - Chasman, D.I.

AU - Clark, G.R.

AU - Cummings, S.R.

AU - Danoy, P.

AU - Dennison, E.M.

AU - Eastell, R.

AU - Eisman, J.A.

AU - Gudnason, V.

AU - Hofman, A.

AU - Jackson, R.D.

AU - Jones, G.

AU - Jukema, J.W.

AU - Khaw, K.-T.

AU - Lehtimäki, T.

AU - Liu, Y.

AU - Lorentzon, M.

AU - Mccloskey, E.

AU - Mitchell, B.D.

AU - Nandakumar, K.

AU - Nicholson, G.C.

AU - Oostra, B.A.

AU - Peacock, M.

AU - Pols, H.A.P.

AU - Prince, Richard

AU - Raitakari, O.

AU - Reid, I.R.

AU - Robbins, J.

AU - Sambrook, P.N.

AU - Sham, P.C.

AU - Shuldiner, A.R.

AU - Tylavsky, F.A.

AU - Van Duijn, C.M.

AU - Wareham, N.J.

AU - Cupples, L.A.

AU - Econs, M.J.

AU - Evans, D.M.

AU - Harris, T.B.

AU - Kung, A.W.C.

AU - Psaty, B.M.

AU - Reeve, J.

AU - Spector, T.D.

AU - Streeten, E.A.

AU - Zillikens, M.C.

AU - Thorsteinsdottir, U.

AU - Ohlsson, C.

AU - Karasik, D.

AU - Richards, J.B.

AU - Brown, M.A.

AU - Stefansson, K.

AU - Uitterlinden, A.G.

AU - Ralston, S.H.

AU - Ioannidis, J.P.A.

AU - Kiel, D.P.

AU - Rivadeneira, F.

PY - 2012

Y1 - 2012

U2 - 10.1038/ng.2249

DO - 10.1038/ng.2249

M3 - Article

SN - 1061-4036

VL - 44

SP - 491

EP - 503

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -