Genome-wide diversity in the California condor tracks its prehistoric abundance and decline

Jacqueline A. Robinson, Rauri C.K. Bowie, Olga Dudchenko, Erez Lieberman Aiden, Sher L. Hendrickson, Cynthia C. Steiner, Oliver A. Ryder, David P. Mindell, Jeffrey D. Wall

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Due to their small population sizes, threatened and endangered species frequently suffer from a lack of genetic diversity, potentially leading to inbreeding depression and reduced adaptability.1 During the latter half of the twentieth century, North America's largest soaring bird,2 the California condor (Gymnogyps californianus; Critically Endangered3), briefly went extinct in the wild. Though condors once ranged throughout North America, by 1982 only 22 individuals remained. Following decades of captive breeding and release efforts, there are now >300 free-flying wild condors and ∼200 in captivity. The condor's recent near-extinction from lead poisoning, poaching, and loss of habitat is well documented,4 but much about its history remains obscure. To fill this gap and aid future management of the species, we produced a high-quality chromosome-length genome assembly for the California condor and analyzed its genome-wide diversity. For comparison, we also examined the genomes of two close relatives: the Andean condor (Vultur gryphus; Vulnerable3) and the turkey vulture (Cathartes aura; Least Concern3). The genomes of all three species show evidence of historic population declines. Interestingly, the California condor genome retains a high degree of variation, which our analyses reveal is a legacy of its historically high abundance. Correlations between genome-wide diversity and recombination rate further suggest a history of purifying selection against linked deleterious alleles, boding well for future restoration. We show how both long-term evolutionary forces and recent inbreeding have shaped the genome of the California condor, and provide crucial genomic resources to enable future research and conservation.

Original languageEnglish
Pages (from-to)2939-2946.e5
JournalCurrent Biology
Volume31
Issue number13
DOIs
Publication statusPublished - 12 Jul 2021

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