Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study

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Abstract

This genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels measured in blood collected at age 6 years (n=673) and at age 14 years (n=1140). Replication of significantly associated genes from previous GWASs was found for both ages. Genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in PDE3B/CYP2R1 (age 6: rs1007392, P=3.9 × 10−8; age14: rs11023332, P=2.2 × 10−10) and on chromosome 4q13 in GC (age 6: rs17467825, P=4.2 × 10−9; age14: rs1155563; P=3.9 × 10−9). In addition, a novel association was observed at age 6 with SNPs on chromosome 7p15 near NPY (age 6: rs156299, P=1.3 × 10−6) that could be of functional interest in highlighting alternative pathways for vitamin D metabolism in this age group and merits further analysis in other cohort studies.
Original languageEnglish
Pages (from-to)578-583
JournalGenes and Immunity
Volume15
Early online date11 Sep 2014
DOIs
Publication statusPublished - Dec 2014

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