Genome wide association study of substance use disorder in the United Arab Emirates

Hiba Ghuloum Alblooshi

Research output: ThesisDoctoral Thesis

138 Downloads (Pure)

Abstract

This study presents the first Genome Wide Association Study (GWAS) in patients diagnosed with Substance Use Disorder
(SUD) from the United Arab Emirates. The GWAS discovery cohort consisted of 250 cases and 262 controls male participants that were genotyped using lllumina OmniExome5 microarray. The GWAS association analysis identified three potential Single Nucleotides Polymorphisms (SNPs) on chromosome 7, that were highly suggestive. In addition, a subsequent analysis in which the data was stratified based on the common substance of use (opioid), revealed association between haplotypes on chromosome 2 and opioid use disorder. This study identified two candidate regions that carry novel associations with SUD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date2 Oct 2018
DOIs
Publication statusUnpublished - 2018

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