Abstract
This study presents the first Genome Wide Association Study (GWAS) in patients diagnosed with Substance Use Disorder
(SUD) from the United Arab Emirates. The GWAS discovery cohort consisted of 250 cases and 262 controls male participants that were genotyped using lllumina OmniExome5 microarray. The GWAS association analysis identified three potential Single Nucleotides Polymorphisms (SNPs) on chromosome 7, that were highly suggestive. In addition, a subsequent analysis in which the data was stratified based on the common substance of use (opioid), revealed association between haplotypes on chromosome 2 and opioid use disorder. This study identified two candidate regions that carry novel associations with SUD.
(SUD) from the United Arab Emirates. The GWAS discovery cohort consisted of 250 cases and 262 controls male participants that were genotyped using lllumina OmniExome5 microarray. The GWAS association analysis identified three potential Single Nucleotides Polymorphisms (SNPs) on chromosome 7, that were highly suggestive. In addition, a subsequent analysis in which the data was stratified based on the common substance of use (opioid), revealed association between haplotypes on chromosome 2 and opioid use disorder. This study identified two candidate regions that carry novel associations with SUD.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 2 Oct 2018 |
DOIs | |
Publication status | Unpublished - 2018 |