@article{707d86dd22cd469b8c8881d6ba2ba993,
title = "Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma",
abstract = "Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10-8 to P = 10-190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.",
author = "{Alcohol Genome-wide Association (AlcGen) Consortium} and {Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study} and {Genetic Investigation of Anthropometric Traits (GIANT) Consortium} and {Global Lipids Genetics Consortium} and {Genetics of Liver Disease (GOLD) Consortium} and {International Consortium for Blood Pressure (ICBP-GWAS)} and {Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)} and Chambers, {J. C.} and W. Zhang and J. Sehmi and X. Li and Wass, {M. N.} and {Van der Harst}, P. and H. Holm and S. Sanna and M. Kavousi and Baumeister, {S. E.} and Coin, {L. J.} and G. Deng and C. Gieger and Heard-Costa, {N. L.} and Hottenga, {J. J.} and B. K{\"u}hnel and V. Kumar and V. Lagou and L. Liang and J. Luan and Vidal, {P. M.} and {Mateo Leach}, I. and O'reilly, {P. F.} and Peden, {J. F.} and N. Rahmioglu and P. Soininen and Speliotes, {E. K.} and X. Yuan and G. Thorleifsson and Alizadeh, {B. Z.} and Atwood, {L. D.} and Borecki, {I. B.} and Brown, {M. J.} and P. Charoen and F. Cucca and D. Das and {de Geus}, {E. J.} and Dixon, {A. L.} and A. D{\"o}ring and G. Ehret and Eyjolfsson, {G. I.} and M. Farrall and Forouhi, {N. G.} and N. Friedrich and W. Goessling and Gudbjartsson, {D. F.} and Harris, {T. B.} and Hartikainen, {A. L.} and S. Heath and Hirschfield, {G. M.} and A. Hofman and G. Homuth and E. Hypp{\"o}nen and Janssen, {H. L.} and T. Johnson and Kangas, {A. J.} and Kema, {I. P.} and K{\"u}hn, {J. P.} and S. Lai and M. Lathrop and Lerch, {M. M.} and Y. Li and Liang, {T. J.} and Lin, {J. P.} and Loos, {R. J.} and Martin, {N. G.} and Moffatt, {M. F.} and Montgomery, {G. W.} and Munroe, {P. B.} and K. Musunuru and Y. Nakamura and O'donnell, {C. J.} and I. Olafsson and Penninx, {B. W.} and A. Pouta and Prins, {B. P.} and I. Prokopenko and R. Puls and A. Ruokonen and Savolainen, {M. J.} and D. Schlessinger and Schouten, {J. N.} and U. Seedorf and S. Sen-Chowdhry and Siminovitch, {K. A.} and Smit, {J. H.} and Spector, {T. D.} and W. Tan and Teslovich, {T. M.} and T. Tukiainen and Uitterlinden, {A. G.} and {Van der Klauw}, {M. M.} and Vasan, {R. S.} and C. Wallace and H. Wallaschofski and Wichmann, {H. E.} and G. Willemsen and P. W{\"u}rtz and C. Xu and Yerges-Armstrong, {L. M.} and Abecasis, {G. R.} and Ahmadi, {K. R.} and Boomsma, {D. I.} and M. Caulfield and Cookson, {W. O.} and {van Duijn}, {C. M.} and P. Froguel and K. Matsuda and McCarthy, {M. I.} and C. Meisinger and V. Mooser and Pietil{\"a}inen, {K. H.} and G. Schumann and H. Snieder and Sternberg, {M. J.} and Stolk, {R. P.} and Thomas, {H. C.} and U. Thorsteinsdottir and M. Uda and G. Waeber and Wareham, {N. J.} and Waterworth, {D. M.} and H. Watkins and Whitfield, {J. B.} and Witteman, {J. C.} and Wolffenbuttel, {B. H.} and Fox, {C. S.} and M. Ala-Korpela and K. Stefansson and P. Vollenweider and H. V{\"o}lzke and Schadt, {E. E.} and J. Scott and J{\"a}rvelin, {M. R.} and P. Elliott and Kooner, {J. S.} and Voight, {B. F.} and Scott, {L. J.} and V. Steinthorsdottir and Morris, {A. P.} and C. Dina and Welch, {R. P.} and E. Zeggini and C. Huth and Aulchenko, {Y. S.} and McCulloch, {L. J.} and T. Ferreira and H. Grallert and N. Amin and G. Wu and Willer, {C. J.} and S. Raychaudhuri and McCarroll, {S. A.} and C. Langenberg and Hofmann, {O. M.} and J. Dupuis and L. Qi and Segr{\`e}, {A. V.} and {van Hoek}, M. and P. Navarro and Ardlie, {K. G.} and B. Balkau and R. Benediktsson and Bennett, {A. J.} and R. Blagieva and E. Boerwinkle and Bonnycastle, {L. L.} and {Bengtsson Bostr{\"o}m}, K. and B. Bravenboer and S. Bumpstead and Burtt, {N. P.} and G. Charpentier and Chines, {P. S.} and M. Cornelis and Couper, {D. J.} and G. Crawford and Doney, {A. S.} and Elliott, {K. S.} and Elliott, {A. L.} and Erdos, {M. R.} and Franklin, {C. S.} and M. Ganser and N. Grarup and T. Green and S. Griffin and Groves, {C. J.} and C. Guiducci and S. Hadjadj and N. Hassanali and C. Herder and B. Isomaa and Jackson, {A. U.} and Johnson, {P. R.} and T. J{\o}rgensen and Kao, {W. H.} and N. Klopp and A. Kong and P. Kraft and J. Kuusisto and T. Lauritzen and M. Li and A. Lieverse and Lindgren, {C. M.} and V. Lyssenko and M. Marre and T. Meitinger and K. Midthjell and Morken, {M. A.} and N. Narisu and P. Nilsson and Owen, {K. R.} and F. Payne and Perry, {J. R.} and Petersen, {A. K.} and Platou, {C. G.} and C. Proen{\cc}a and W. Rathmann and {William Rayner}, N. and Robertson, {N. R.} and G. Rocheleau and M. Roden and Sampson, {M. J.} and R. Saxena and Shields, {B. M.} and P. Shrader and G. Sigurdsson and T. Spars{\o} and K. Strassburger and Stringham, {H. M.} and Q. Sun and Swift, {A. J.} and B. Thorand and J. Tichet and T. Tuomi and {van Dam}, {R. M.} and {van Haeften}, {T. W.} and {van Herpt}, T. and {van Vliet-Ostaptchouk}, {J. V.} and Walters, {G. B.} and Weedon, {M. N.} and C. Wijmenga and Bergman, {R. N.} and S. Cauchi and Collins, {F. S.} and J. Hui and Beilby, {J. P.} and Musk, {A. W.} and N. Hammond and Hillman, {D. R.} and S. Mukherjee",
year = "2011",
month = "11",
day = "1",
doi = "10.1038/ng.970",
language = "English",
volume = "43",
pages = "1131--1138",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "11",
}