Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

L.D.W. Oei, K. Estrada, E.L. Duncan, C.S. Christiansen, C. Liu, B.L. Langdahl, B.M. Obermayer-Pietsch, J.A. Riancho, Richard Prince, N.M. Van Schoor, E.V. Mccloskey, Y. Hsu, E. Evangelou, E.E. Ntzani, D.M. Evans, N. Alonso, L.B. Husted, C.T. Valero, J.L.Z. Hernández, Joshua Lewis & 34 others S.K. Kaptoge, Kun Zhu, L.A. Cupples, C. Medina-Gõmez, L. Vandenput, G. Kim, S. Lee, M.C. Castaño-Betancourt, E.H.G. Oei, J.M.O. Martínez, A. Daroszewska, M. Van Der Klift, D.D. Mellström, L. Herrera, M.K. Karlsson, A. Hofman, O. Ljunggren, H.A.P. Pols, L. Stolk, J.B.J. Van Meurs, J.P.A. Ioannidis, M.C.C. Zillikens, P.J.A. Lips, D. Karasik, A.G. Uitterlinden, U. Styrkársdóttir, M.A. Brown, J. Koh, J.B. Richards, J. Reeve, C. Ohlsson, S.H. Ralston, D.P. Kiel, F.F. Rivadeneira

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    Abstract

    Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size
    Original languageEnglish
    Pages (from-to)20-27
    JournalBone
    Volume59
    DOIs
    Publication statusPublished - 2014

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    Genome-Wide Association Study
    Single Nucleotide Polymorphism
    Logistic Models
    Osteoporotic Fractures
    Genetic Predisposition to Disease
    Meta-Analysis
    Genome
    Population

    Cite this

    Oei, L. D. W., Estrada, K., Duncan, E. L., Christiansen, C. S., Liu, C., Langdahl, B. L., ... Rivadeneira, F. F. (2014). Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone, 59, 20-27. https://doi.org/10.1016/j.bone.2013.10.015
    Oei, L.D.W. ; Estrada, K. ; Duncan, E.L. ; Christiansen, C.S. ; Liu, C. ; Langdahl, B.L. ; Obermayer-Pietsch, B.M. ; Riancho, J.A. ; Prince, Richard ; Van Schoor, N.M. ; Mccloskey, E.V. ; Hsu, Y. ; Evangelou, E. ; Ntzani, E.E. ; Evans, D.M. ; Alonso, N. ; Husted, L.B. ; Valero, C.T. ; Hernández, J.L.Z. ; Lewis, Joshua ; Kaptoge, S.K. ; Zhu, Kun ; Cupples, L.A. ; Medina-Gõmez, C. ; Vandenput, L. ; Kim, G. ; Lee, S. ; Castaño-Betancourt, M.C. ; Oei, E.H.G. ; Martínez, J.M.O. ; Daroszewska, A. ; Van Der Klift, M. ; Mellström, D.D. ; Herrera, L. ; Karlsson, M.K. ; Hofman, A. ; Ljunggren, O. ; Pols, H.A.P. ; Stolk, L. ; Van Meurs, J.B.J. ; Ioannidis, J.P.A. ; Zillikens, M.C.C. ; Lips, P.J.A. ; Karasik, D. ; Uitterlinden, A.G. ; Styrkársdóttir, U. ; Brown, M.A. ; Koh, J. ; Richards, J.B. ; Reeve, J. ; Ohlsson, C. ; Ralston, S.H. ; Kiel, D.P. ; Rivadeneira, F.F. / Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. In: Bone. 2014 ; Vol. 59. pp. 20-27.
    @article{54f33b7d78f747a2a91e96dc9d875923,
    title = "Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus",
    abstract = "Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size",
    author = "L.D.W. Oei and K. Estrada and E.L. Duncan and C.S. Christiansen and C. Liu and B.L. Langdahl and B.M. Obermayer-Pietsch and J.A. Riancho and Richard Prince and {Van Schoor}, N.M. and E.V. Mccloskey and Y. Hsu and E. Evangelou and E.E. Ntzani and D.M. Evans and N. Alonso and L.B. Husted and C.T. Valero and J.L.Z. Hern{\'a}ndez and Joshua Lewis and S.K. Kaptoge and Kun Zhu and L.A. Cupples and C. Medina-G{\~o}mez and L. Vandenput and G. Kim and S. Lee and M.C. Casta{\~n}o-Betancourt and E.H.G. Oei and J.M.O. Mart{\'i}nez and A. Daroszewska and {Van Der Klift}, M. and D.D. Mellstr{\"o}m and L. Herrera and M.K. Karlsson and A. Hofman and O. Ljunggren and H.A.P. Pols and L. Stolk and {Van Meurs}, J.B.J. and J.P.A. Ioannidis and M.C.C. Zillikens and P.J.A. Lips and D. Karasik and A.G. Uitterlinden and U. Styrk{\'a}rsd{\'o}ttir and M.A. Brown and J. Koh and J.B. Richards and J. Reeve and C. Ohlsson and S.H. Ralston and D.P. Kiel and F.F. Rivadeneira",
    year = "2014",
    doi = "10.1016/j.bone.2013.10.015",
    language = "English",
    volume = "59",
    pages = "20--27",
    journal = "Bone",
    issn = "8756-3282",
    publisher = "Academic Press",

    }

    Oei, LDW, Estrada, K, Duncan, EL, Christiansen, CS, Liu, C, Langdahl, BL, Obermayer-Pietsch, BM, Riancho, JA, Prince, R, Van Schoor, NM, Mccloskey, EV, Hsu, Y, Evangelou, E, Ntzani, EE, Evans, DM, Alonso, N, Husted, LB, Valero, CT, Hernández, JLZ, Lewis, J, Kaptoge, SK, Zhu, K, Cupples, LA, Medina-Gõmez, C, Vandenput, L, Kim, G, Lee, S, Castaño-Betancourt, MC, Oei, EHG, Martínez, JMO, Daroszewska, A, Van Der Klift, M, Mellström, DD, Herrera, L, Karlsson, MK, Hofman, A, Ljunggren, O, Pols, HAP, Stolk, L, Van Meurs, JBJ, Ioannidis, JPA, Zillikens, MCC, Lips, PJA, Karasik, D, Uitterlinden, AG, Styrkársdóttir, U, Brown, MA, Koh, J, Richards, JB, Reeve, J, Ohlsson, C, Ralston, SH, Kiel, DP & Rivadeneira, FF 2014, 'Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus' Bone, vol. 59, pp. 20-27. https://doi.org/10.1016/j.bone.2013.10.015

    Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. / Oei, L.D.W.; Estrada, K.; Duncan, E.L.; Christiansen, C.S.; Liu, C.; Langdahl, B.L.; Obermayer-Pietsch, B.M.; Riancho, J.A.; Prince, Richard; Van Schoor, N.M.; Mccloskey, E.V.; Hsu, Y.; Evangelou, E.; Ntzani, E.E.; Evans, D.M.; Alonso, N.; Husted, L.B.; Valero, C.T.; Hernández, J.L.Z.; Lewis, Joshua; Kaptoge, S.K.; Zhu, Kun; Cupples, L.A.; Medina-Gõmez, C.; Vandenput, L.; Kim, G.; Lee, S.; Castaño-Betancourt, M.C.; Oei, E.H.G.; Martínez, J.M.O.; Daroszewska, A.; Van Der Klift, M.; Mellström, D.D.; Herrera, L.; Karlsson, M.K.; Hofman, A.; Ljunggren, O.; Pols, H.A.P.; Stolk, L.; Van Meurs, J.B.J.; Ioannidis, J.P.A.; Zillikens, M.C.C.; Lips, P.J.A.; Karasik, D.; Uitterlinden, A.G.; Styrkársdóttir, U.; Brown, M.A.; Koh, J.; Richards, J.B.; Reeve, J.; Ohlsson, C.; Ralston, S.H.; Kiel, D.P.; Rivadeneira, F.F.

    In: Bone, Vol. 59, 2014, p. 20-27.

    Research output: Contribution to journal › Article

    TY - JOUR

    T1 - Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

    AU - Oei, L.D.W.

    AU - Estrada, K.

    AU - Duncan, E.L.

    AU - Christiansen, C.S.

    AU - Liu, C.

    AU - Langdahl, B.L.

    AU - Obermayer-Pietsch, B.M.

    AU - Riancho, J.A.

    AU - Prince, Richard

    AU - Van Schoor, N.M.

    AU - Mccloskey, E.V.

    AU - Hsu, Y.

    AU - Evangelou, E.

    AU - Ntzani, E.E.

    AU - Evans, D.M.

    AU - Alonso, N.

    AU - Husted, L.B.

    AU - Valero, C.T.

    AU - Hernández, J.L.Z.

    AU - Lewis, Joshua

    AU - Kaptoge, S.K.

    AU - Zhu, Kun

    AU - Cupples, L.A.

    AU - Medina-Gõmez, C.

    AU - Vandenput, L.

    AU - Kim, G.

    AU - Lee, S.

    AU - Castaño-Betancourt, M.C.

    AU - Oei, E.H.G.

    AU - Martínez, J.M.O.

    AU - Daroszewska, A.

    AU - Van Der Klift, M.

    AU - Mellström, D.D.

    AU - Herrera, L.

    AU - Karlsson, M.K.

    AU - Hofman, A.

    AU - Ljunggren, O.

    AU - Pols, H.A.P.

    AU - Stolk, L.

    AU - Van Meurs, J.B.J.

    AU - Ioannidis, J.P.A.

    AU - Zillikens, M.C.C.

    AU - Lips, P.J.A.

    AU - Karasik, D.

    AU - Uitterlinden, A.G.

    AU - Styrkársdóttir, U.

    AU - Brown, M.A.

    AU - Koh, J.

    AU - Richards, J.B.

    AU - Reeve, J.

    AU - Ohlsson, C.

    AU - Ralston, S.H.

    AU - Kiel, D.P.

    AU - Rivadeneira, F.F.

    PY - 2014

    Y1 - 2014

    N2 - Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size

    AB - Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size

    U2 - 10.1016/j.bone.2013.10.015

    DO - 10.1016/j.bone.2013.10.015

    M3 - Article

    VL - 59

    SP - 20

    EP - 27

    JO - Bone

    JF - Bone

    SN - 8756-3282

    ER -

    Oei LDW, Estrada K, Duncan EL, Christiansen CS, Liu C, Langdahl BL et al. Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone. 2014;59:20-27. https://doi.org/10.1016/j.bone.2013.10.015

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