Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

J.C. Barrett; D.G. Clayton; P. Concannon; B. Akolkar; J.D. Cooper; H.A. Erlich; C. Julier; Grant Morahan; J. Nerup; C. Nierraas; V. Plagnol; F. Pociot; H. Schuilenburg; D.J. Smyth; H. Stevens; J.A. Todd; N.M. Walker; S.S. Rich

doi:10.1038/ng.381

Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

J.C. Barrett, D.G. Clayton, P. Concannon, B. Akolkar, J.D. Cooper, H.A. Erlich, C. Julier, Grant Morahan, J. Nerup, C. Nierraas, V. Plagnol, F. Pociot, H. Schuilenburg, D.J. Smyth, H. Stevens, J.A. Todd, N.M. Walker, S.S. Rich

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

1403 Citations (Scopus)

Abstract

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P <10^sup -6^). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P <0.01; overall P <5 × 10^sup -8^) and 4 additional regions provided nominal evidence of replication (P <0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. [PUBLICATION ABSTRACT]

Original language	English
Pages (from-to)	703-707
Number of pages	5
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.381
Publication status	Published - 10 May 2009

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Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierraas, C., Plagnol, V., Pociot, F., Schuilenburg, H., Smyth, D. J., Stevens, H., Todd, J. A., Walker, N. M., & Rich, S. S. (2009). Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, 41(6), 703-707. https://doi.org/10.1038/ng.381

@article{d670c8faaa0f4f8a9933942de2c40652,

title = "Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes",

abstract = "Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P <10^sup -6^). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P <0.01; overall P <5 × 10^sup -8^) and 4 additional regions provided nominal evidence of replication (P <0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. [PUBLICATION ABSTRACT]",

author = "J.C. Barrett and D.G. Clayton and P. Concannon and B. Akolkar and J.D. Cooper and H.A. Erlich and C. Julier and Grant Morahan and J. Nerup and C. Nierraas and V. Plagnol and F. Pociot and H. Schuilenburg and D.J. Smyth and H. Stevens and J.A. Todd and N.M. Walker and S.S. Rich",

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Barrett, JC, Clayton, DG, Concannon, P, Akolkar, B, Cooper, JD, Erlich, HA, Julier, C, Morahan, G, Nerup, J, Nierraas, C, Plagnol, V, Pociot, F, Schuilenburg, H, Smyth, DJ, Stevens, H, Todd, JA, Walker, NM & Rich, SS 2009, 'Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes', Nature Genetics, vol. 41, no. 6, pp. 703-707. https://doi.org/10.1038/ng.381

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T1 - Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

AU - Barrett, J.C.

AU - Clayton, D.G.

AU - Concannon, P.

AU - Akolkar, B.

AU - Cooper, J.D.

AU - Erlich, H.A.

AU - Julier, C.

AU - Morahan, Grant

AU - Nerup, J.

AU - Nierraas, C.

AU - Plagnol, V.

AU - Pociot, F.

AU - Schuilenburg, H.

AU - Smyth, D.J.

AU - Stevens, H.

AU - Todd, J.A.

AU - Walker, N.M.

AU - Rich, S.S.

PY - 2009/5/10

Y1 - 2009/5/10

N2 - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P <10^sup -6^). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P <0.01; overall P <5 × 10^sup -8^) and 4 additional regions provided nominal evidence of replication (P <0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. [PUBLICATION ABSTRACT]

AB - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P <10^sup -6^). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P <0.01; overall P <5 × 10^sup -8^) and 4 additional regions provided nominal evidence of replication (P <0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27. [PUBLICATION ABSTRACT]

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DO - 10.1038/ng.381

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SN - 1061-4036

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SP - 703

EP - 707

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Genome-wide Association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Abstract

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