Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

A. Ramasamy; M. Kuokkanen; S. Vedantam; Z.K. Gajdos; A. Couto Alves; H.N. Lyon; M.A.R. Ferreira; D.P. Strachan; J.H. Zhao; M.J. Abramson; M.A. Brown; L. Coin; S.C. Dharmage; D.L. Duffy; T. Haahtela; A.C. Heath; C. Janson; M. Kähönen; K.-T. Khaw; J. Laitinen; Peter Le Souef; T. Lehtimäki; P.A.F. Madden; G.B. Marks; N.G. Martin; M.C. Matheson; C.D. Palmer; A. Palotie; A. Pouta; C.F. Robertson; J. Viikari; E. Widen; M. Wjst; D.L. Jarvis; G.W. Montgomery; Philip Thompson; N. Wareham; J. Eriksson; P. Jousilahti; T. Laitinen; J. Pekkanen; O.T. Raitakari; G.T. O'Connor; V. Salomaa; M.-R. Jarvelin; J.N. Hirschhorn

doi:10.1371/journal.pone.0044008

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

A. Ramasamy, M. Kuokkanen, S. Vedantam, Z.K. Gajdos, A. Couto Alves, H.N. Lyon, M.A.R. Ferreira, D.P. Strachan, J.H. Zhao, M.J. Abramson, M.A. Brown, L. Coin, S.C. Dharmage, D.L. Duffy, T. Haahtela, A.C. Heath, C. Janson, M. Kähönen, K.-T. Khaw, J. LaitinenPeter Le Souef, T. Lehtimäki, P.A.F. Madden, G.B. Marks, N.G. Martin, M.C. Matheson, C.D. Palmer, A. Palotie, A. Pouta, C.F. Robertson, J. Viikari, E. Widen, M. Wjst, D.L. Jarvis, G.W. Montgomery, Philip Thompson, N. Wareham, J. Eriksson, P. Jousilahti, T. Laitinen, J. Pekkanen, O.T. Raitakari, G.T. O'Connor, V. Salomaa, M.-R. Jarvelin, J.N. Hirschhorn

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Abstract

[Truncated abstract] Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P

Original language	English
Pages (from-to)	10pp
Journal	PLoS One
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0044008
Publication status	Published - 28 Sept 2012

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Ramasamy, A., Kuokkanen, M., Vedantam, S., Gajdos, Z. K., Couto Alves, A., Lyon, H. N., Ferreira, M. A. R., Strachan, D. P., Zhao, J. H., Abramson, M. J., Brown, M. A., Coin, L., Dharmage, S. C., Duffy, D. L., Haahtela, T., Heath, A. C., Janson, C., Kähönen, M., Khaw, K.-T., ... Hirschhorn, J. N. (2012). Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA. PLoS One, 7(9), 10pp. https://doi.org/10.1371/journal.pone.0044008

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title = "Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA",

abstract = "[Truncated abstract] Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P",

author = "A. Ramasamy and M. Kuokkanen and S. Vedantam and Z.K. Gajdos and {Couto Alves}, A. and H.N. Lyon and M.A.R. Ferreira and D.P. Strachan and J.H. Zhao and M.J. Abramson and M.A. Brown and L. Coin and S.C. Dharmage and D.L. Duffy and T. Haahtela and A.C. Heath and C. Janson and M. K{\"a}h{\"o}nen and K.-T. Khaw and J. Laitinen and {Le Souef}, Peter and T. Lehtim{\"a}ki and P.A.F. Madden and G.B. Marks and N.G. Martin and M.C. Matheson and C.D. Palmer and A. Palotie and A. Pouta and C.F. Robertson and J. Viikari and E. Widen and M. Wjst and D.L. Jarvis and G.W. Montgomery and Philip Thompson and N. Wareham and J. Eriksson and P. Jousilahti and T. Laitinen and J. Pekkanen and O.T. Raitakari and G.T. O'Connor and V. Salomaa and M.-R. Jarvelin and J.N. Hirschhorn",

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Ramasamy, A, Kuokkanen, M, Vedantam, S, Gajdos, ZK, Couto Alves, A, Lyon, HN, Ferreira, MAR, Strachan, DP, Zhao, JH, Abramson, MJ, Brown, MA, Coin, L, Dharmage, SC, Duffy, DL, Haahtela, T, Heath, AC, Janson, C, Kähönen, M, Khaw, K-T, Laitinen, J, Le Souef, P, Lehtimäki, T, Madden, PAF, Marks, GB, Martin, NG, Matheson, MC, Palmer, CD, Palotie, A, Pouta, A, Robertson, CF, Viikari, J, Widen, E, Wjst, M, Jarvis, DL, Montgomery, GW, Thompson, P, Wareham, N, Eriksson, J, Jousilahti, P, Laitinen, T, Pekkanen, J, Raitakari, OT, O'Connor, GT, Salomaa, V, Jarvelin, M-R & Hirschhorn, JN 2012, 'Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA', PLoS One, vol. 7, no. 9, pp. 10pp. https://doi.org/10.1371/journal.pone.0044008

TY - JOUR

T1 - Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

AU - Ramasamy, A.

AU - Kuokkanen, M.

AU - Vedantam, S.

AU - Gajdos, Z.K.

AU - Couto Alves, A.

AU - Lyon, H.N.

AU - Ferreira, M.A.R.

AU - Strachan, D.P.

AU - Zhao, J.H.

AU - Abramson, M.J.

AU - Brown, M.A.

AU - Coin, L.

AU - Dharmage, S.C.

AU - Duffy, D.L.

AU - Haahtela, T.

AU - Heath, A.C.

AU - Janson, C.

AU - Kähönen, M.

AU - Khaw, K.-T.

AU - Laitinen, J.

AU - Le Souef, Peter

AU - Lehtimäki, T.

AU - Madden, P.A.F.

AU - Marks, G.B.

AU - Martin, N.G.

AU - Matheson, M.C.

AU - Palmer, C.D.

AU - Palotie, A.

AU - Pouta, A.

AU - Robertson, C.F.

AU - Viikari, J.

AU - Widen, E.

AU - Wjst, M.

AU - Jarvis, D.L.

AU - Montgomery, G.W.

AU - Thompson, Philip

AU - Wareham, N.

AU - Eriksson, J.

AU - Jousilahti, P.

AU - Laitinen, T.

AU - Pekkanen, J.

AU - Raitakari, O.T.

AU - O'Connor, G.T.

AU - Salomaa, V.

AU - Jarvelin, M.-R.

AU - Hirschhorn, J.N.

PY - 2012/9/28

Y1 - 2012/9/28

N2 - [Truncated abstract] Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P

AB - [Truncated abstract] Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations.Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P

U2 - 10.1371/journal.pone.0044008

DO - 10.1371/journal.pone.0044008

M3 - Article

C2 - 23028483

SN - 1932-6203

VL - 7

SP - 10pp

JO - PLoS One

JF - PLoS One

IS - 9

ER -

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

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