Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder

Jessica Lasky-Su; Richard J L Anney; Benjamin M Neale; Barbara Franke; Kaixin Zhou; Julian B Maller; Alejandro Arias Vasquez; Wai Chen; Philip Asherson; Jan Buitelaar; Tobias Banaschewski; Richard Ebstein; Michael Gill; Ana Miranda; Fernando Mulas; Robert D Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Edmund Sonuga-Barke; Hans Christoph Steinhausen; Eric Taylor; Mark Daly; Nan Laird; Christoph Lange; Stephen V Faraone

doi:10.1002/ajmg.b.30869

Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder

Jessica Lasky-Su, Richard J L Anney, Benjamin M Neale, Barbara Franke, Kaixin Zhou, Julian B Maller, Alejandro Arias Vasquez, Wai Chen, Philip Asherson, Jan Buitelaar, Tobias Banaschewski, Richard Ebstein, Michael Gill, Ana Miranda, Fernando Mulas, Robert D Oades, Herbert Roeyers, Aribert Rothenberger, Joseph Sergeant, Edmund Sonuga-BarkeHans Christoph Steinhausen, Eric Taylor, Mark Daly, Nan Laird, Christoph Lange, Stephen V Faraone

UWA Medical School

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.

Original language	English
Pages (from-to)	1355-8
Number of pages	4
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	147B
Issue number	8
DOIs	https://doi.org/10.1002/ajmg.b.30869
Publication status	Published - 5 Dec 2008

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Lasky-Su, J., Anney, R. J. L., Neale, B. M., Franke, B., Zhou, K., Maller, J. B., Vasquez, A. A., Chen, W., Asherson, P., Buitelaar, J., Banaschewski, T., Ebstein, R., Gill, M., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., ... Faraone, S. V. (2008). Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(8), 1355-8. https://doi.org/10.1002/ajmg.b.30869

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title = "Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder",

abstract = "A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.",

keywords = "Adolescent, Age of Onset, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Female, Genetic Markers, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Haplotypes, Humans, Linkage Disequilibrium, Male, Pedigree, Polymorphism, Single Nucleotide, Probability, Quantitative Trait Loci, Retrospective Studies, Sodium-Hydrogen Exchangers, Journal Article, Research Support, N.I.H., Extramural",

author = "Jessica Lasky-Su and Anney, {Richard J L} and Neale, {Benjamin M} and Barbara Franke and Kaixin Zhou and Maller, {Julian B} and Vasquez, {Alejandro Arias} and Wai Chen and Philip Asherson and Jan Buitelaar and Tobias Banaschewski and Richard Ebstein and Michael Gill and Ana Miranda and Fernando Mulas and Oades, {Robert D} and Herbert Roeyers and Aribert Rothenberger and Joseph Sergeant and Edmund Sonuga-Barke and Steinhausen, {Hans Christoph} and Eric Taylor and Mark Daly and Nan Laird and Christoph Lange and Faraone, {Stephen V}",

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Lasky-Su, J, Anney, RJL, Neale, BM, Franke, B, Zhou, K, Maller, JB, Vasquez, AA, Chen, W, Asherson, P, Buitelaar, J, Banaschewski, T, Ebstein, R, Gill, M, Miranda, A, Mulas, F, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Sonuga-Barke, E, Steinhausen, HC, Taylor, E, Daly, M, Laird, N, Lange, C & Faraone, SV 2008, 'Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 147B, no. 8, pp. 1355-8. https://doi.org/10.1002/ajmg.b.30869

TY - JOUR

T1 - Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder

AU - Lasky-Su, Jessica

AU - Anney, Richard J L

AU - Neale, Benjamin M

AU - Franke, Barbara

AU - Zhou, Kaixin

AU - Maller, Julian B

AU - Vasquez, Alejandro Arias

AU - Chen, Wai

AU - Asherson, Philip

AU - Buitelaar, Jan

AU - Banaschewski, Tobias

AU - Ebstein, Richard

AU - Gill, Michael

AU - Miranda, Ana

AU - Mulas, Fernando

AU - Oades, Robert D

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph

AU - Sonuga-Barke, Edmund

AU - Steinhausen, Hans Christoph

AU - Taylor, Eric

AU - Daly, Mark

AU - Laird, Nan

AU - Lange, Christoph

AU - Faraone, Stephen V

PY - 2008/12/5

Y1 - 2008/12/5

N2 - A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.

AB - A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.

KW - Adolescent

KW - Age of Onset

KW - Attention Deficit Disorder with Hyperactivity

KW - Child

KW - Child, Preschool

KW - Female

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Probability

KW - Quantitative Trait Loci

KW - Retrospective Studies

KW - Sodium-Hydrogen Exchangers

KW - Journal Article

KW - Research Support, N.I.H., Extramural

U2 - 10.1002/ajmg.b.30869

DO - 10.1002/ajmg.b.30869

M3 - Article

C2 - 18937294

SN - 1552-4841

VL - 147B

SP - 1355

EP - 1358

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 8

ER -

Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder

Abstract

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