Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 669-677 |
| Journal | Nature Genetics |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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Genome-wide association analysis identifies six new loci associated with forced vital capacity. / Loth, D.W.; Artigas, M.S.; Gharib, S.A.; Wain, L.V.; Franceschini, N.; Koch, B.; Pottinger, T.D.; Smith, A.V.; Duan, Q.; Oldmeadow, C.J.; Lee, M.; Strachan, D.P.; James, Alan; Huffman, J.E.; Vitart, V.; Ramasamy, A.; Wareham, N.J.; Kaprio, J.; Wang, X.; Trochet, H.; Kähönen, M.; Flexeder, C.; Albrecht, E.; Lopez, L.M.; De Jong, K.; Thyagarajan, B.; Alves, A.C.; Enroth, S.; Omenaas, E.R.; Joshi, P.K.; Fall, T.; Viñuela, A.; Launer, L.J.; Loehr, L.R.; Fornage, M.; Li, G.; Wilk, J.B.; Tang, W.; Manichaikul, A.; Lahousse, L.; Harris, T.B.; North, K.E.; Rudnicka, A.R.; Hui, Jennie; Gu, X.; Lumley, T.S.; Wright, A.F.; Hastie, N.D.; Campbell, S.; Kumar, R.; Pin, I.; Scott, R.A.; Pietiláinen, K.H.; Surakka, I.; Liu, Y.; Holliday, E.G.; Schulz, H.; Heinrich, J.; Davies, G.C.; Vonk, J.M.; Wojczynski, M.K.; Pouta, A.M.; Johansson, A.M.; Wild, S.H.; Ingelsson, E.; Rivadeneira, F.F.; Völzke, H.; Hysi, P.G.; Eiríksdóttir, G.; Morrison, A.C.; Rotter, J.I.; Gao, W.; Postma, D.S.; White, W.B.; Rich, S.S.; Hofman, A.; Aspelund, T.; Couper, D.J.; Smith, L.J.; Psaty, B.M.; Lohman, K.K.; Burchard, E.G.; Uitterlinden, A.G.; Garcia, M.E.; Joubert, B.R.; Mcardle, W.L.; Musk, A.W.B.M.; Hansel, N.N.; Heckbert, S.R.; Zgaga, L.; Van Meurs, J.B.J.; Navarro, P.; Rudan, I.; Oh, Y.; Redline, S.; Jarvis, D.L.; Zhao, J.; Rantanen, T.; O'Connor, G.T.; Ripatti, S.O.; Scott, R.J.; Karrasch, S.; Grallert, H.; Gaddis, N.C.; Starr, J.M.; Wijmenga, C.; Minster, R.L.; Lederer, D.J.; Pekkanen, J.J.; Gyllensten, U.B.; Campbell, H.S.; Morris, A.P.; Gläser, S.; Hammond, C.J.; Burkart, K.M.; Beilby, John; Kritchevsky, S.B.; Gudnason, V.G.; Hancock, D.B.; Williams, O.D.; Polašek, O.; Zemunik, T.; Kolčić, I.; Petrini, M.F.; Wjst, M.; Kim, W.; Porteous, D.J.; Scotland, G.; Smith, B.H.; Viljanen, A.; Heliövaara, M.M.; Attia, J.R.; Sayers, I.; Hampel, R.; Gieger, C.; Deary, I.J.; Boezen, H.M.; Newman, A.B.; Järvelin, M.R.; Wilson, J.F.F.; Lind, L.; Stricker, B.C.C.H.; Teumer, A.; Spector, T.D.; Melén, E.; Peters, M.J.; Lange, L.A.; Barr, R.G.; Bracke, K.R.; Verhamme, F.M.; Sung, J.; Hiemstra, P.S.; Cassano, P.A.; Sood, A.; Hayward, C.; Dupuis, J.P.; Hall, I.P.; Brusselle, G.G.; Tobin, M.D.; London, S.J.
In: Nature Genetics, Vol. 46, No. 7, 2014, p. 669-677.Research output: Contribution to journal › Article
TY - JOUR
T1 - Genome-wide association analysis identifies six new loci associated with forced vital capacity
AU - Loth, D.W.
AU - Artigas, M.S.
AU - Gharib, S.A.
AU - Wain, L.V.
AU - Franceschini, N.
AU - Koch, B.
AU - Pottinger, T.D.
AU - Smith, A.V.
AU - Duan, Q.
AU - Oldmeadow, C.J.
AU - Lee, M.
AU - Strachan, D.P.
AU - James, Alan
AU - Huffman, J.E.
AU - Vitart, V.
AU - Ramasamy, A.
AU - Wareham, N.J.
AU - Kaprio, J.
AU - Wang, X.
AU - Trochet, H.
AU - Kähönen, M.
AU - Flexeder, C.
AU - Albrecht, E.
AU - Lopez, L.M.
AU - De Jong, K.
AU - Thyagarajan, B.
AU - Alves, A.C.
AU - Enroth, S.
AU - Omenaas, E.R.
AU - Joshi, P.K.
AU - Fall, T.
AU - Viñuela, A.
AU - Launer, L.J.
AU - Loehr, L.R.
AU - Fornage, M.
AU - Li, G.
AU - Wilk, J.B.
AU - Tang, W.
AU - Manichaikul, A.
AU - Lahousse, L.
AU - Harris, T.B.
AU - North, K.E.
AU - Rudnicka, A.R.
AU - Hui, Jennie
AU - Gu, X.
AU - Lumley, T.S.
AU - Wright, A.F.
AU - Hastie, N.D.
AU - Campbell, S.
AU - Kumar, R.
AU - Pin, I.
AU - Scott, R.A.
AU - Pietiláinen, K.H.
AU - Surakka, I.
AU - Liu, Y.
AU - Holliday, E.G.
AU - Schulz, H.
AU - Heinrich, J.
AU - Davies, G.C.
AU - Vonk, J.M.
AU - Wojczynski, M.K.
AU - Pouta, A.M.
AU - Johansson, A.M.
AU - Wild, S.H.
AU - Ingelsson, E.
AU - Rivadeneira, F.F.
AU - Völzke, H.
AU - Hysi, P.G.
AU - Eiríksdóttir, G.
AU - Morrison, A.C.
AU - Rotter, J.I.
AU - Gao, W.
AU - Postma, D.S.
AU - White, W.B.
AU - Rich, S.S.
AU - Hofman, A.
AU - Aspelund, T.
AU - Couper, D.J.
AU - Smith, L.J.
AU - Psaty, B.M.
AU - Lohman, K.K.
AU - Burchard, E.G.
AU - Uitterlinden, A.G.
AU - Garcia, M.E.
AU - Joubert, B.R.
AU - Mcardle, W.L.
AU - Musk, A.W.B.M.
AU - Hansel, N.N.
AU - Heckbert, S.R.
AU - Zgaga, L.
AU - Van Meurs, J.B.J.
AU - Navarro, P.
AU - Rudan, I.
AU - Oh, Y.
AU - Redline, S.
AU - Jarvis, D.L.
AU - Zhao, J.
AU - Rantanen, T.
AU - O'Connor, G.T.
AU - Ripatti, S.O.
AU - Scott, R.J.
AU - Karrasch, S.
AU - Grallert, H.
AU - Gaddis, N.C.
AU - Starr, J.M.
AU - Wijmenga, C.
AU - Minster, R.L.
AU - Lederer, D.J.
AU - Pekkanen, J.J.
AU - Gyllensten, U.B.
AU - Campbell, H.S.
AU - Morris, A.P.
AU - Gläser, S.
AU - Hammond, C.J.
AU - Burkart, K.M.
AU - Beilby, John
AU - Kritchevsky, S.B.
AU - Gudnason, V.G.
AU - Hancock, D.B.
AU - Williams, O.D.
AU - Polašek, O.
AU - Zemunik, T.
AU - Kolčić, I.
AU - Petrini, M.F.
AU - Wjst, M.
AU - Kim, W.
AU - Porteous, D.J.
AU - Scotland, G.
AU - Smith, B.H.
AU - Viljanen, A.
AU - Heliövaara, M.M.
AU - Attia, J.R.
AU - Sayers, I.
AU - Hampel, R.
AU - Gieger, C.
AU - Deary, I.J.
AU - Boezen, H.M.
AU - Newman, A.B.
AU - Järvelin, M.R.
AU - Wilson, J.F.F.
AU - Lind, L.
AU - Stricker, B.C.C.H.
AU - Teumer, A.
AU - Spector, T.D.
AU - Melén, E.
AU - Peters, M.J.
AU - Lange, L.A.
AU - Barr, R.G.
AU - Bracke, K.R.
AU - Verhamme, F.M.
AU - Sung, J.
AU - Hiemstra, P.S.
AU - Cassano, P.A.
AU - Sood, A.
AU - Hayward, C.
AU - Dupuis, J.P.
AU - Hall, I.P.
AU - Brusselle, G.G.
AU - Tobin, M.D.
AU - London, S.J.
PY - 2014
Y1 - 2014
N2 - Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P <5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.© 2014 Nature America, Inc. All rights reserved.
AB - Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P <5 × 10-8) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.© 2014 Nature America, Inc. All rights reserved.
U2 - 10.1038/ng.3011
DO - 10.1038/ng.3011
M3 - Article
VL - 46
SP - 669
EP - 677
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 7
ER -