Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Heng Chooi, J. Fang, H. Liu, S.G. Filler, P. Wang, Y. Tang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent. © 2013 American Chemical Society.
Original languageEnglish
Pages (from-to)780-783
JournalOrganic Letters
Volume15
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Neosartorya
Dimethylallyltranstransferase
Polyketides
Aspergillus
Aspergillus fumigatus
T-cells
fungi
genome
metabolites
X ray crystallography
X Ray Crystallography
Immunosuppressive Agents
Metabolites
Fungi
crystallography
isolation
Genes
Chemical activation
Nuclear magnetic resonance
activation

Cite this

Chooi, Heng ; Fang, J. ; Liu, H. ; Filler, S.G. ; Wang, P. ; Tang, Y. / Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. In: Organic Letters. 2013 ; Vol. 15, No. 4. pp. 780-783.
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Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. / Chooi, Heng; Fang, J.; Liu, H.; Filler, S.G.; Wang, P.; Tang, Y.

In: Organic Letters, Vol. 15, No. 4, 2013, p. 780-783.

Research output: Contribution to journalArticle

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AU - Tang, Y.

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