Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Heng Chooi; J. Fang; H. Liu; S.G. Filler; P. Wang; Y. Tang

doi:10.1021/ol303435y

Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Heng Chooi, J. Fang, H. Liu, S.G. Filler, P. Wang, Y. Tang

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent. © 2013 American Chemical Society.

Original language	English
Pages (from-to)	780-783
Journal	Organic Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/ol303435y
Publication status	Published - 2013

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title = "Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi",

abstract = "Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent. {\textcopyright} 2013 American Chemical Society.",

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journal = "Organic Letters",

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T1 - Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

AU - Chooi, Heng

AU - Fang, J.

AU - Liu, H.

AU - Filler, S.G.

AU - Wang, P.

AU - Tang, Y.

PY - 2013

Y1 - 2013

N2 - Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent. © 2013 American Chemical Society.

AB - Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent. © 2013 American Chemical Society.

U2 - 10.1021/ol303435y

DO - 10.1021/ol303435y

M3 - Article

VL - 15

SP - 780

EP - 783

JO - Organic Letters

JF - Organic Letters

SN - 1523-7052

IS - 4

ER -

Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Abstract

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