Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

the Early Growth Genetics Consortium

doi:10.1186/s12920-022-01281-1

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

the Early Growth Genetics Consortium

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4 Citations (Scopus)

Abstract

Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

Original language	English
Article number	124
Number of pages	16
Journal	BMC Medical Genomics
Volume	15
DOIs	https://doi.org/10.1186/s12920-022-01281-1
Publication status	Published - 4 Jun 2022

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10.1186/s12920-022-01281-1Licence: CC BY

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@article{74f6776d69c342c3827ea0a812c4427b,

title = "Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes",

abstract = "Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.",

keywords = "Genetic correlations, Genome-wide association study, Head circumference, Infancy",

author = "{the Early Growth Genetics Consortium} and Suzanne Vogelezang and Bradfield, {Jonathan P.} and Stefan Johansson and Evie Stergiakouli and Elisabeth Thiering and Pennell, {Craig E.} and Ahluwalia, {Tarunveer S.} and Ville Karhunen and Markus Scholz and Xueping Liu and Carmen I{\~n}iguez and Raitakari, {Olli T.} and Jonas Bacelis and Schnurr, {Theresia M.} and Lakka, {Timo A.} and Ioanna Ntalla and Lind, {Mads V.} and Lotte Lauritzen and Sauli Herrala and Lin, {Frederick T.J.} and Christine Frithioff-B{\o}js{\o}e and Beaumont, {Robin N.} and Zafarmand, {Mohammed H.} and Peter Rzehak and Bilbao, {Jose R.} and Nella Junna and Vonk, {Judith M.} and Rifas-Shiman, {Sheryl L.} and Janjanam, {Vimala D.} and Knol, {Maria J.} and Shweta Ramdas and Lawrie Beilin and Klaus B{\o}nnelykke and Maribel Casas and Eriksson, {Johan G.} and Joaquin Escribano and Evans, {Tavia E.} and Ulrike Gehring and Frank Geller and Veit Grote and Darek Gruszfeld and Hakon Hakonarson and Hattersley, {Andrew T.} and Have, {Christian T.} and {Geoffrey Hayes}, M. and Joachim Heinrich and {\O}vind Helgeland and Jhon Holloway and Raimo Joro and Julius Juodakis and Knight, {Bridget A.} and Bert Koletzko and Antje K{\"o}rner and Langhendries, {Jean Paul} and Leinonen, {Jaakko T.} and Virpi Lindi and Lund, {Morten A.V.} and Stephen Lye and Mads Melbye and Michaelsen, {Kim F.} and Morgen, {Camilla S.} and Harri Niinikoski and Katja Pahkala and Kalliope Panoutsopoulou and Oluf Pedersen and Fernando Rivadeneira and Loreto Santa-Marina and Schaik, {Barbera D.C.} and Denise Scholtens and Sylvain Sebert and Ibon Tamayo and Timpson, {Nicholas J.} and Maties Torrent and Uitterlinden, {Andr{\'e} G.} and Marc Vaudel and Elvira Verduci and Rebecca Vinding and Mandy Vogel and Eleftheria Zeggini and Christopher Brown and Adams, {Hieab H.H.} and Wilfried Karmaus and Hivert, {Marie France} and Koppelman, {Gerard H.} and Elisabeth Wid{\'e}n and Nora Fernandez-Jimenez and Melanie Waldenberger and Vrijkotte, {Tanja G.M.} and Freathy, {Rachel M.} and Holm, {Jens Christian} and Lowe, {William L.} and Niels Grarup and Torben Hansen and Dedoussis, {George V.} and Mustafa Atalay and Nohr, {Ellen A.} and Bo Jacobsson and Niina Pitk{\"a}nen and Martine Vrijheid and Bjarke Feenstra and Wieland Kiess and Jarvelin, {Marjo Riita} and Hans Bisgaard and {Wang C}, Carol and Marie Standl and McCarthy, {Mark I.} and Pourcain, {Beate St} and Nj{\o}lstad, {P{\aa}l R.} and Grant, {Struan F.A.} and Felix, {Janine F.} and Jaddoe, {Vincent W.V.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jun,

day = "4",

doi = "10.1186/s12920-022-01281-1",

language = "English",

volume = "15",

journal = "BMC Medical Genomics",

issn = "1755-8794",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

AU - the Early Growth Genetics Consortium

AU - Vogelezang, Suzanne

AU - Bradfield, Jonathan P.

AU - Johansson, Stefan

AU - Stergiakouli, Evie

AU - Thiering, Elisabeth

AU - Pennell, Craig E.

AU - Ahluwalia, Tarunveer S.

AU - Karhunen, Ville

AU - Scholz, Markus

AU - Liu, Xueping

AU - Iñiguez, Carmen

AU - Raitakari, Olli T.

AU - Bacelis, Jonas

AU - Schnurr, Theresia M.

AU - Lakka, Timo A.

AU - Ntalla, Ioanna

AU - Lind, Mads V.

AU - Lauritzen, Lotte

AU - Herrala, Sauli

AU - Lin, Frederick T.J.

AU - Frithioff-Bøjsøe, Christine

AU - Beaumont, Robin N.

AU - Zafarmand, Mohammed H.

AU - Rzehak, Peter

AU - Bilbao, Jose R.

AU - Junna, Nella

AU - Vonk, Judith M.

AU - Rifas-Shiman, Sheryl L.

AU - Janjanam, Vimala D.

AU - Knol, Maria J.

AU - Ramdas, Shweta

AU - Beilin, Lawrie

AU - Bønnelykke, Klaus

AU - Casas, Maribel

AU - Eriksson, Johan G.

AU - Escribano, Joaquin

AU - Evans, Tavia E.

AU - Gehring, Ulrike

AU - Geller, Frank

AU - Grote, Veit

AU - Gruszfeld, Darek

AU - Hakonarson, Hakon

AU - Hattersley, Andrew T.

AU - Have, Christian T.

AU - Geoffrey Hayes, M.

AU - Heinrich, Joachim

AU - Helgeland, Øvind

AU - Holloway, Jhon

AU - Joro, Raimo

AU - Juodakis, Julius

AU - Knight, Bridget A.

AU - Koletzko, Bert

AU - Körner, Antje

AU - Langhendries, Jean Paul

AU - Leinonen, Jaakko T.

AU - Lindi, Virpi

AU - Lund, Morten A.V.

AU - Lye, Stephen

AU - Melbye, Mads

AU - Michaelsen, Kim F.

AU - Morgen, Camilla S.

AU - Niinikoski, Harri

AU - Pahkala, Katja

AU - Panoutsopoulou, Kalliope

AU - Pedersen, Oluf

AU - Rivadeneira, Fernando

AU - Santa-Marina, Loreto

AU - Schaik, Barbera D.C.

AU - Scholtens, Denise

AU - Sebert, Sylvain

AU - Tamayo, Ibon

AU - Timpson, Nicholas J.

AU - Torrent, Maties

AU - Uitterlinden, André G.

AU - Vaudel, Marc

AU - Verduci, Elvira

AU - Vinding, Rebecca

AU - Vogel, Mandy

AU - Zeggini, Eleftheria

AU - Brown, Christopher

AU - Adams, Hieab H.H.

AU - Karmaus, Wilfried

AU - Hivert, Marie France

AU - Koppelman, Gerard H.

AU - Widén, Elisabeth

AU - Fernandez-Jimenez, Nora

AU - Waldenberger, Melanie

AU - Vrijkotte, Tanja G.M.

AU - Freathy, Rachel M.

AU - Holm, Jens Christian

AU - Lowe, William L.

AU - Grarup, Niels

AU - Hansen, Torben

AU - Dedoussis, George V.

AU - Atalay, Mustafa

AU - Nohr, Ellen A.

AU - Jacobsson, Bo

AU - Pitkänen, Niina

AU - Vrijheid, Martine

AU - Feenstra, Bjarke

AU - Kiess, Wieland

AU - Jarvelin, Marjo Riita

AU - Bisgaard, Hans

AU - Wang C, Carol

AU - Standl, Marie

AU - McCarthy, Mark I.

AU - Pourcain, Beate St

AU - Njølstad, Pål R.

AU - Grant, Struan F.A.

AU - Felix, Janine F.

AU - Jaddoe, Vincent W.V.

PY - 2022/6/4

Y1 - 2022/6/4

N2 - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

AB - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

KW - Genetic correlations

KW - Genome-wide association study

KW - Head circumference

KW - Infancy

UR - http://www.scopus.com/inward/record.url?scp=85137679586&partnerID=8YFLogxK

U2 - 10.1186/s12920-022-01281-1

DO - 10.1186/s12920-022-01281-1

M3 - Article

C2 - 35659227

AN - SCOPUS:85137679586

SN - 1755-8794

VL - 15

JO - BMC Medical Genomics

JF - BMC Medical Genomics

M1 - 124

ER -

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

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