Abstract
[Truncated] Lipoprotein lipase (LPL) and hepatic lipase (HL) play key roles in the metabolism of lipoprotein particles. Genetic variation in these lipases has been associated with altered plasma lipid profiles, dyslipidaemias and progression of cardiovascular disease. The effects of such variation in a diabetic metabolic context are not well known. This thesis reports studies of three common polymorphisms of the LPL gene (D9N, N291S and S447X), and one promoter polymorphism of the HL (or LIPC) gene (C-514T) in 432 Type 1 diabetic subjects and in 403 Type 2 diabetic subjects, and compares the findings to those previously described in a non-diabetic cohort.
| Original language | English |
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| Qualification | Masters |
| Awarding Institution |
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| DOIs | |
| Publication status | Unpublished - 2002 |
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- Brownrigg_Leon_M_2002
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