Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1

Tony Scalzo, P.A. Lyons, N.A. Fitzgerald, Catherine Forbes, W.M. Yokoyama, Geoffrey Shellam

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Abstract

The Cmv1 resistance gene controls splenic replication of murine cytomegalovirus (MCMV) and confers natural killer (MZ) cell-mediated resistance to otherwise lethal infection. The Cmv1 phenotypes of 13 inbred mouse strains have been assessed, and it was found that the Cmv1(r) resistance phenotype was restricted to the C57BL/6J and Ma/MyJ strains. We have further analyzed the linkage of Cmv1 to the NK gene complex (NKC) mapping to distal mouse chromosome 6 in 99 (BALB/c x C57BL/6J)F-1 x BALB/c backcross mice using cloned gene probes and microsatellite markers from this region. No recombinants were observed between Cmv1 and the NRC-associated Ly49 and musNKR-P1 multigene families, nor the Kap locus, nor with 7 microsatellite markers, indicating that Cmv1 is closely linked (
Original languageEnglish
Pages (from-to)435-441
JournalGenomics
Volume27
DOIs
Publication statusPublished - 1995

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    Scalzo, T., Lyons, P. A., Fitzgerald, N. A., Forbes, C., Yokoyama, W. M., & Shellam, G. (1995). Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1. Genomics, 27, 435-441. https://doi.org/10.1006/geno.1995.1074