Genetic Loci for Retinal Arteriolar Microcirculation

X. Sim, R.A. Jensen, M.K. Ikram, M.F. Cotch, X. Li, S. Macgregor, J. Xie, A.V. Smith, E. Boerwinkle, P. Mitchell, R. Klein, B.E.K. Klein, N.L. Glazer, T. Lumley, B. Mcknight, B.M. Psaty, P.T.V.M. De Jong, A. Hofman, F. Rivadeneira, A.G. UitterlindenC.M. Van Duijn, T. Aspelund, G. Eiríksdóttir, T.B. Harris, F. Jónasson, L.J. Launer, J. Attia, P.N. Baird, S. Harrap, E.G. Holliday, M. Inouye, E. Rochtchina, R.J. Scott, A. Viswanathan, G. Li, N.L. Smith, K.L. Wiggins, J.Z. Kuo, K.D. Taylor, Alex Hewitt, N.G. Martin, G.W. Montgomery, C. Sun, T.L. Young, David Mackey, N.R. Van Zuydam, A.S.F. Doney, C.N.A. Palmer, A.D. Morris, J.I. Rotter, E.S. Tai, V. Gudnason, J.R. Vingerling, D.S. Siscovick, J.J. Wang, T.Y. Wong

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value
Original languageEnglish
Pages (from-to)12pp
JournalPLoS One
Issue number6
Publication statusPublished - 2013


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