Genetic Loci for Retinal Arteriolar Microcirculation

X. Sim; R.A. Jensen; M.K. Ikram; M.F. Cotch; X. Li; S. Macgregor; J. Xie; A.V. Smith; E. Boerwinkle; P. Mitchell; R. Klein; B.E.K. Klein; N.L. Glazer; T. Lumley; B. Mcknight; B.M. Psaty; P.T.V.M. De Jong; A. Hofman; F. Rivadeneira; A.G. Uitterlinden; C.M. Van Duijn; T. Aspelund; G. Eiríksdóttir; T.B. Harris; F. Jónasson; L.J. Launer; J. Attia; P.N. Baird; S. Harrap; E.G. Holliday; M. Inouye; E. Rochtchina; R.J. Scott; A. Viswanathan; G. Li; N.L. Smith; K.L. Wiggins; J.Z. Kuo; K.D. Taylor; Alex Hewitt; N.G. Martin; G.W. Montgomery; C. Sun; T.L. Young; David Mackey; N.R. Van Zuydam; A.S.F. Doney; C.N.A. Palmer; A.D. Morris; J.I. Rotter; E.S. Tai; V. Gudnason; J.R. Vingerling; D.S. Siscovick; J.J. Wang; T.Y. Wong

doi:10.1371/journal.pone.0065804

Genetic Loci for Retinal Arteriolar Microcirculation

X. Sim, R.A. Jensen, M.K. Ikram, M.F. Cotch, X. Li, S. Macgregor, J. Xie, A.V. Smith, E. Boerwinkle, P. Mitchell, R. Klein, B.E.K. Klein, N.L. Glazer, T. Lumley, B. Mcknight, B.M. Psaty, P.T.V.M. De Jong, A. Hofman, F. Rivadeneira, A.G. UitterlindenC.M. Van Duijn, T. Aspelund, G. Eiríksdóttir, T.B. Harris, F. Jónasson, L.J. Launer, J. Attia, P.N. Baird, S. Harrap, E.G. Holliday, M. Inouye, E. Rochtchina, R.J. Scott, A. Viswanathan, G. Li, N.L. Smith, K.L. Wiggins, J.Z. Kuo, K.D. Taylor, Alex Hewitt, N.G. Martin, G.W. Montgomery, C. Sun, T.L. Young, David Mackey, N.R. Van Zuydam, A.S.F. Doney, C.N.A. Palmer, A.D. Morris, J.I. Rotter, E.S. Tai, V. Gudnason, J.R. Vingerling, D.S. Siscovick, J.J. Wang, T.Y. Wong

Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value

Original language	English
Pages (from-to)	12pp
Journal	PLoS One
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0065804
Publication status	Published - 2013

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Sim, X., Jensen, R. A., Ikram, M. K., Cotch, M. F., Li, X., Macgregor, S., Xie, J., Smith, A. V., Boerwinkle, E., Mitchell, P., Klein, R., Klein, B. E. K., Glazer, N. L., Lumley, T., Mcknight, B., Psaty, B. M., De Jong, P. T. V. M., Hofman, A., Rivadeneira, F., ... Wong, T. Y. (2013). Genetic Loci for Retinal Arteriolar Microcirculation. PLoS One, 8(6), 12pp. https://doi.org/10.1371/journal.pone.0065804

@article{4971b0de88104158b73230eb15ea3d5f,

title = "Genetic Loci for Retinal Arteriolar Microcirculation",

abstract = "Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value",

author = "X. Sim and R.A. Jensen and M.K. Ikram and M.F. Cotch and X. Li and S. Macgregor and J. Xie and A.V. Smith and E. Boerwinkle and P. Mitchell and R. Klein and B.E.K. Klein and N.L. Glazer and T. Lumley and B. Mcknight and B.M. Psaty and {De Jong}, P.T.V.M. and A. Hofman and F. Rivadeneira and A.G. Uitterlinden and {Van Duijn}, C.M. and T. Aspelund and G. Eir{\'i}ksd{\'o}ttir and T.B. Harris and F. J{\'o}nasson and L.J. Launer and J. Attia and P.N. Baird and S. Harrap and E.G. Holliday and M. Inouye and E. Rochtchina and R.J. Scott and A. Viswanathan and G. Li and N.L. Smith and K.L. Wiggins and J.Z. Kuo and K.D. Taylor and Alex Hewitt and N.G. Martin and G.W. Montgomery and C. Sun and T.L. Young and David Mackey and {Van Zuydam}, N.R. and A.S.F. Doney and C.N.A. Palmer and A.D. Morris and J.I. Rotter and E.S. Tai and V. Gudnason and J.R. Vingerling and D.S. Siscovick and J.J. Wang and T.Y. Wong",

year = "2013",

doi = "10.1371/journal.pone.0065804",

language = "English",

volume = "8",

pages = "12pp",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science (PLoS)",

number = "6",

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Sim, X, Jensen, RA, Ikram, MK, Cotch, MF, Li, X, Macgregor, S, Xie, J, Smith, AV, Boerwinkle, E, Mitchell, P, Klein, R, Klein, BEK, Glazer, NL, Lumley, T, Mcknight, B, Psaty, BM, De Jong, PTVM, Hofman, A, Rivadeneira, F, Uitterlinden, AG, Van Duijn, CM, Aspelund, T, Eiríksdóttir, G, Harris, TB, Jónasson, F, Launer, LJ, Attia, J, Baird, PN, Harrap, S, Holliday, EG, Inouye, M, Rochtchina, E, Scott, RJ, Viswanathan, A, Li, G, Smith, NL, Wiggins, KL, Kuo, JZ, Taylor, KD, Hewitt, A, Martin, NG, Montgomery, GW, Sun, C, Young, TL, Mackey, D, Van Zuydam, NR, Doney, ASF, Palmer, CNA, Morris, AD, Rotter, JI, Tai, ES, Gudnason, V, Vingerling, JR, Siscovick, DS, Wang, JJ & Wong, TY 2013, 'Genetic Loci for Retinal Arteriolar Microcirculation', PLoS One, vol. 8, no. 6, pp. 12pp. https://doi.org/10.1371/journal.pone.0065804

TY - JOUR

T1 - Genetic Loci for Retinal Arteriolar Microcirculation

AU - Sim, X.

AU - Jensen, R.A.

AU - Ikram, M.K.

AU - Cotch, M.F.

AU - Li, X.

AU - Macgregor, S.

AU - Xie, J.

AU - Smith, A.V.

AU - Boerwinkle, E.

AU - Mitchell, P.

AU - Klein, R.

AU - Klein, B.E.K.

AU - Glazer, N.L.

AU - Lumley, T.

AU - Mcknight, B.

AU - Psaty, B.M.

AU - De Jong, P.T.V.M.

AU - Hofman, A.

AU - Rivadeneira, F.

AU - Uitterlinden, A.G.

AU - Van Duijn, C.M.

AU - Aspelund, T.

AU - Eiríksdóttir, G.

AU - Harris, T.B.

AU - Jónasson, F.

AU - Launer, L.J.

AU - Attia, J.

AU - Baird, P.N.

AU - Harrap, S.

AU - Holliday, E.G.

AU - Inouye, M.

AU - Rochtchina, E.

AU - Scott, R.J.

AU - Viswanathan, A.

AU - Li, G.

AU - Smith, N.L.

AU - Wiggins, K.L.

AU - Kuo, J.Z.

AU - Taylor, K.D.

AU - Hewitt, Alex

AU - Martin, N.G.

AU - Montgomery, G.W.

AU - Sun, C.

AU - Young, T.L.

AU - Mackey, David

AU - Van Zuydam, N.R.

AU - Doney, A.S.F.

AU - Palmer, C.N.A.

AU - Morris, A.D.

AU - Rotter, J.I.

AU - Tai, E.S.

AU - Gudnason, V.

AU - Vingerling, J.R.

AU - Siscovick, D.S.

AU - Wang, J.J.

AU - Wong, T.Y.

PY - 2013

Y1 - 2013

N2 - Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value

AB - Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value

U2 - 10.1371/journal.pone.0065804

DO - 10.1371/journal.pone.0065804

M3 - Article

SN - 1932-6203

VL - 8

SP - 12pp

JO - PLoS One

JF - PLoS One

IS - 6

ER -

Genetic Loci for Retinal Arteriolar Microcirculation

Abstract

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