Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation

A. K. Gedeon, I. A. Glass, J. M. Connor, J. C. Mulley

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 1991], with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (θ = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsatellite markers. Peak pairwise lod scares of 4.02 and 4.01 (θ = 0.00) were attained at the DXS1114 and DXS994 loci respectively. This MRX gene is now designated MRX27 and is localised to Xq24-26 by recombination events detected by DXS424 and DXS102. This regional localisation spans 26.2 cM an the genetic background map and defines another distinct MRX interval by linkage to a specific region of the X chromosome.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume64
Issue number1
DOIs
Publication statusPublished - 12 Jul 1996
Externally publishedYes

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