Genetic association of preeclampsia to the inflammatory response gene SEPS1

E.K. Moses, M.P. Johnson, L. Tommerdal, S. Forsmo, J.E. Curran, Lawrence Abraham, J.C. Charlesworth, S.P. Brennecke, J. Blangero, R. Austgulen

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    OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses.RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.
    Original languageEnglish
    Pages (from-to)336.e-336.e5
    JournalAmerican Journal of Obstetrics and Gynecology
    Publication statusPublished - 2008


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