Genetic association of preeclampsia to the inflammatory response gene SEPS1

E.K. Moses; M.P. Johnson; L. Tommerdal; S. Forsmo; J.E. Curran; Lawrence Abraham; J.C. Charlesworth; S.P. Brennecke; J. Blangero; R. Austgulen

doi:10.1016/j.ajog.2007.09.024

Genetic association of preeclampsia to the inflammatory response gene SEPS1

E.K. Moses, M.P. Johnson, L. Tommerdal, S. Forsmo, J.E. Curran, Lawrence Abraham, J.C. Charlesworth, S.P. Brennecke, J. Blangero, R. Austgulen

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Abstract

OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses.RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

Original language	English
Pages (from-to)	336.e-336.e5
Journal	American Journal of Obstetrics and Gynecology
Volume	198
DOIs	https://doi.org/10.1016/j.ajog.2007.09.024
Publication status	Published - 2008

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10.1016/j.ajog.2007.09.024

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title = "Genetic association of preeclampsia to the inflammatory response gene SEPS1",

abstract = "OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses.RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.",

author = "E.K. Moses and M.P. Johnson and L. Tommerdal and S. Forsmo and J.E. Curran and Lawrence Abraham and J.C. Charlesworth and S.P. Brennecke and J. Blangero and R. Austgulen",

year = "2008",

doi = "10.1016/j.ajog.2007.09.024",

language = "English",

volume = "198",

pages = "336.e--336.e5",

journal = "American Journal of Obstetrics & Gynecology",

issn = "0002-9378",

publisher = "Elsevier - Mosby",

}

TY - JOUR

T1 - Genetic association of preeclampsia to the inflammatory response gene SEPS1

AU - Moses, E.K.

AU - Johnson, M.P.

AU - Tommerdal, L.

AU - Forsmo, S.

AU - Curran, J.E.

AU - Abraham, Lawrence

AU - Charlesworth, J.C.

AU - Brennecke, S.P.

AU - Blangero, J.

AU - Austgulen, R.

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses.RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

AB - OBJECTIVE: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.STUDY DESIGN: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n=1139) and control (n=2269) women. Statistical significance was determined by chi(2) and multivariate regression analyses.RESULTS: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P=.0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P=.023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.

U2 - 10.1016/j.ajog.2007.09.024

DO - 10.1016/j.ajog.2007.09.024

M3 - Article

VL - 198

SP - 336.e-336.e5

JO - American Journal of Obstetrics & Gynecology

JF - American Journal of Obstetrics & Gynecology

SN - 0002-9378

ER -

Genetic association of preeclampsia to the inflammatory response gene SEPS1

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