Genetic approaches in preeclampsia

Hannah E.J. Yong, Padma Murthi, Shaun P. Brennecke, Eric K. Moses

Research output: Chapter in Book/Conference paperChapter

8 Citations (Scopus)

Abstract

Preeclampsia (PE) is a serious hypertensive disorder that affects up to 8% of all pregnancies annually. An established risk factor for PE is family history, clearly demonstrating an underlying genetic component to the disorder. To date, numerous genetic studies, using both the candidate gene and genome-wide approach, have been undertaken to tease out the genetic basis of PE and understand its origins. Such studies have identified some promising candidate genes such as STOX1 and ACVR2A. Nevertheless, researchers face ongoing challenges of replicating these genetic associations in different populations and performing the functional validation of identified genetic variants to determine their causality in the disorder. This chapter will review the genetic approaches used in the study of PE, discuss their limitations and possible confounders, and describe current strategies.

Original languageEnglish
Title of host publicationGenetic Approaches in Preeclampsia
EditorsP Murthi, C Vaillancourt
PublisherHumana Press
Pages53-72
Number of pages20
Volume1710
ISBN (Electronic)9781493974986
ISBN (Print)9781493974979
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameMethods in Molecular Biology
Volume1710
ISSN (Print)1064-3745

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