Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program

UWA Medical School

Research output: Contribution to journal › Review article › peer-review

908 Citations (Scopus)

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Original language	English
Pages (from-to)	1412-1425
Number of pages	14
Journal	Nature Genetics
Volume	50
Issue number	10
DOIs	https://doi.org/10.1038/s41588-018-0205-x
Publication status	Published - 1 Oct 2018

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10.1038/s41588-018-0205-x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284793

Cite this

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title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits",

abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",

author = "{the Million Veteran Program} and Evangelos Evangelou and Warren, {Helen R.} and David Mosen-Ansorena and Borbala Mifsud and Raha Pazoki and He Gao and Georgios Ntritsos and Niki Dimou and Cabrera, {Claudia P.} and Ibrahim Karaman and Ng, {Fu Liang} and Marina Evangelou and Katarzyna Witkowska and Evan Tzanis and Hellwege, {Jacklyn N.} and Ayush Giri and {Velez Edwards}, {Digna R.} and Sun, {Yan V.} and Kelly Cho and Gaziano, {J. Michael} and Wilson, {Peter W.F.} and Tsao, {Philip S.} and Kovesdy, {Csaba P.} and Tonu Esko and Reedik M{\"a}gi and Lili Milani and Peter Almgren and Thibaud Boutin and St{\'e}phanie Debette and Jun Ding and Franco Giulianini and Holliday, {Elizabeth G.} and Jackson, {Anne U.} and Ruifang Li-Gao and Lin, {Wei Yu} and Jian{\textquoteright}an Luan and Massimo Mangino and Christopher Oldmeadow and Prins, {Bram Peter} and Yong Qian and Muralidharan Sargurupremraj and Nabi Shah and Praveen Surendran and S{\'e}bastien Th{\'e}riault and Niek Verweij and Willems, {Sara M.} and Zhao, {Jing Hua} and Philippe Amouyel and John Connell and {de Mutsert}, Ren{\'e}e and Doney, {Alex S.F.} and Martin Farrall and Cristina Menni and Morris, {Andrew D.} and Raymond Noordam and Guillaume Par{\'e} and Poulter, {Neil R.} and Shields, {Denis C.} and Alice Stanton and Simon Thom and Gon{\c c}alo Abecasis and Najaf Amin and Arking, {Dan E.} and Ayers, {Kristin L.} and Barbieri, {Caterina M.} and Chiara Batini and Bis, {Joshua C.} and Tineka Blake and Murielle Bochud and Michael Boehnke and Eric Boerwinkle and Boomsma, {Dorret I.} and Bottinger, {Erwin P.} and Braund, {Peter S.} and Marco Brumat and Archie Campbell and Harry Campbell and Aravinda Chakravarti and Chambers, {John C.} and Ganesh Chauhan and Marina Ciullo and Massimiliano Cocca and Francis Collins and Cordell, {Heather J.} and Gail Davies and Borst, {Martin H.de} and Geus, {Eco J.de} and Deary, {Ian J.} and Joris Deelen and {Del Greco M}, Fabiola and Demirkale, {Cumhur Yusuf} and Marcus D{\"o}rr and Ehret, {Georg B.} and Roberto Elosua and Stefan Enroth and Erzurumluoglu, {A. Mesut} and Teresa Ferreira and Mattias Fr{\aa}nberg and Franco, {Oscar H.} and Ilaria Gandin and Paolo Gasparini and Vilmantas Giedraitis and Christian Gieger and Giorgia Girotto and Anuj Goel and Gow, {Alan J.} and Vilmundur Gudnason and Xiuqing Guo and Ulf Gyllensten and Anders Hamsten and Harris, {Tamara B.} and Harris, {Sarah E.} and Hartman, {Catharina A.} and Havulinna, {Aki S.} and Hicks, {Andrew A.} and Edith Hofer and Albert Hofman and Hottenga, {Jouke Jan} and Huffman, {Jennifer E.} and Hwang, {Shih Jen} and Erik Ingelsson and Alan James and Rick Jansen and Jarvelin, {Marjo Riitta} and Roby Joehanes and {\AA}sa Johansson and Johnson, {Andrew D.} and Joshi, {Peter K.} and Pekka Jousilahti and Jukema, {J. Wouter} and Antti Jula and Mika K{\"a}h{\"o}nen and Sekar Kathiresan and Keavney, {Bernard D.} and Khaw, {Kay Tee} and Paul Knekt and Joanne Knight and Ivana Kolcic and Kooner, {Jaspal S.} and Seppo Koskinen and Kati Kristiansson and Zoltan Kutalik and Maris Laan and Marty Larson and Launer, {Lenore J.} and Benjamin Lehne and Terho Lehtim{\"a}ki and Liewald, {David C.M.} and Li Lin and Lars Lind and Lindgren, {Cecilia M.} and Liu, {Yong Mei} and Loos, {Ruth J.F.} and Lopez, {Lorna M.} and Yingchang Lu and Lyytik{\"a}inen, {Leo Pekka} and Anubha Mahajan and Chrysovalanto Mamasoula and Jaume Marrugat and Jonathan Marten and Yuri Milaneschi and Anna Morgan and Morris, {Andrew P.} and Morrison, {Alanna C.} and Munson, {Peter J.} and Nalls, {Mike A.} and Priyanka Nandakumar and Nelson, {Christopher P.} and Teemu Niiranen and Nolte, {Ilja M.} and Teresa Nutile and Oldehinkel, {Albertine J.} and Oostra, {Ben A.} and O{\textquoteright}Reilly, {Paul F.} and Elin Org and Sandosh Padmanabhan and Walter Palmas and Aarno Palotie and Alison Pattie and Penninx, {Brenda W.J.H.} and Markus Perola and Annette Peters and Ozren Polasek and Pramstaller, {Peter P.} and Nguyen, {Quang Tri} and Raitakari, {Olli T.} and Meixia Ren and Rainer Rettig and Kenneth Rice and Ridker, {Paul M.} and Ried, {Janina S.} and Harri{\"e}tte Riese and Samuli Ripatti and Antonietta Robino and Rose, {Lynda M.} and Rotter, {Jerome I.} and Igor Rudan and Daniela Ruggiero and Yasaman Saba and Sala, {Cinzia F.} and Veikko Salomaa and Samani, {Nilesh J.} and Sarin, {Antti Pekka} and Reinhold Schmidt and Helena Schmidt and Nick Shrine and David Siscovick and Smith, {Albert V.} and Harold Snieder and Siim S{\~o}ber and Rossella Sorice and Starr, {John M.} and Stott, {David J.} and Strachan, {David P.} and Strawbridge, {Rona J.} and Johan Sundstr{\"o}m and Swertz, {Morris A.} and Taylor, {Kent D.} and Alexander Teumer and Tobin, {Martin D.} and Maciej Tomaszewski and Daniela Toniolo and Michela Traglia and Stella Trompet and Jaakko Tuomilehto and Christophe Tzourio and Uitterlinden, {Andr{\'e} G.} and Ahmad Vaez and {van der Most}, {Peter J.} and {van Duijn}, {Cornelia M.} and Vergnaud, {Anne Claire} and Verwoert, {Germaine C.} and Veronique Vitart and Uwe V{\"o}lker and Peter Vollenweider and Dragana Vuckovic and Hugh Watkins and Wild, {Sarah H.} and Gonneke Willemsen and Wilson, {James F.} and Wright, {Alan F.} and Jie Yao and Tatijana Zemunik and Weihua Zhang and Attia, {John R.} and Butterworth, {Adam S.} and Chasman, {Daniel I.} and David Conen and Francesco Cucca and John Danesh",

year = "2018",

month = oct,

day = "1",

doi = "10.1038/s41588-018-0205-x",

language = "English",

volume = "50",

pages = "1412--1425",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group - Macmillan Publishers",

number = "10",

}

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - the Million Veteran Program

AU - Evangelou, Evangelos

AU - Warren, Helen R.

AU - Mosen-Ansorena, David

AU - Mifsud, Borbala

AU - Pazoki, Raha

AU - Gao, He

AU - Ntritsos, Georgios

AU - Dimou, Niki

AU - Cabrera, Claudia P.

AU - Karaman, Ibrahim

AU - Ng, Fu Liang

AU - Evangelou, Marina

AU - Witkowska, Katarzyna

AU - Tzanis, Evan

AU - Hellwege, Jacklyn N.

AU - Giri, Ayush

AU - Velez Edwards, Digna R.

AU - Sun, Yan V.

AU - Cho, Kelly

AU - Gaziano, J. Michael

AU - Wilson, Peter W.F.

AU - Tsao, Philip S.

AU - Kovesdy, Csaba P.

AU - Esko, Tonu

AU - Mägi, Reedik

AU - Milani, Lili

AU - Almgren, Peter

AU - Boutin, Thibaud

AU - Debette, Stéphanie

AU - Ding, Jun

AU - Giulianini, Franco

AU - Holliday, Elizabeth G.

AU - Jackson, Anne U.

AU - Li-Gao, Ruifang

AU - Lin, Wei Yu

AU - Luan, Jian’an

AU - Mangino, Massimo

AU - Oldmeadow, Christopher

AU - Prins, Bram Peter

AU - Qian, Yong

AU - Sargurupremraj, Muralidharan

AU - Shah, Nabi

AU - Surendran, Praveen

AU - Thériault, Sébastien

AU - Verweij, Niek

AU - Willems, Sara M.

AU - Zhao, Jing Hua

AU - Amouyel, Philippe

AU - Connell, John

AU - de Mutsert, Renée

AU - Doney, Alex S.F.

AU - Farrall, Martin

AU - Menni, Cristina

AU - Morris, Andrew D.

AU - Noordam, Raymond

AU - Paré, Guillaume

AU - Poulter, Neil R.

AU - Shields, Denis C.

AU - Stanton, Alice

AU - Thom, Simon

AU - Abecasis, Gonçalo

AU - Amin, Najaf

AU - Arking, Dan E.

AU - Ayers, Kristin L.

AU - Barbieri, Caterina M.

AU - Batini, Chiara

AU - Bis, Joshua C.

AU - Blake, Tineka

AU - Bochud, Murielle

AU - Boehnke, Michael

AU - Boerwinkle, Eric

AU - Boomsma, Dorret I.

AU - Bottinger, Erwin P.

AU - Braund, Peter S.

AU - Brumat, Marco

AU - Campbell, Archie

AU - Campbell, Harry

AU - Chakravarti, Aravinda

AU - Chambers, John C.

AU - Chauhan, Ganesh

AU - Ciullo, Marina

AU - Cocca, Massimiliano

AU - Collins, Francis

AU - Cordell, Heather J.

AU - Davies, Gail

AU - Borst, Martin H.de

AU - Geus, Eco J.de

AU - Deary, Ian J.

AU - Deelen, Joris

AU - Del Greco M, Fabiola

AU - Demirkale, Cumhur Yusuf

AU - Dörr, Marcus

AU - Ehret, Georg B.

AU - Elosua, Roberto

AU - Enroth, Stefan

AU - Erzurumluoglu, A. Mesut

AU - Ferreira, Teresa

AU - Frånberg, Mattias

AU - Franco, Oscar H.

AU - Gandin, Ilaria

AU - Gasparini, Paolo

AU - Giedraitis, Vilmantas

AU - Gieger, Christian

AU - Girotto, Giorgia

AU - Goel, Anuj

AU - Gow, Alan J.

AU - Gudnason, Vilmundur

AU - Guo, Xiuqing

AU - Gyllensten, Ulf

AU - Hamsten, Anders

AU - Harris, Tamara B.

AU - Harris, Sarah E.

AU - Hartman, Catharina A.

AU - Havulinna, Aki S.

AU - Hicks, Andrew A.

AU - Hofer, Edith

AU - Hofman, Albert

AU - Hottenga, Jouke Jan

AU - Huffman, Jennifer E.

AU - Hwang, Shih Jen

AU - Ingelsson, Erik

AU - James, Alan

AU - Jansen, Rick

AU - Jarvelin, Marjo Riitta

AU - Joehanes, Roby

AU - Johansson, Åsa

AU - Johnson, Andrew D.

AU - Joshi, Peter K.

AU - Jousilahti, Pekka

AU - Jukema, J. Wouter

AU - Jula, Antti

AU - Kähönen, Mika

AU - Kathiresan, Sekar

AU - Keavney, Bernard D.

AU - Khaw, Kay Tee

AU - Knekt, Paul

AU - Knight, Joanne

AU - Kolcic, Ivana

AU - Kooner, Jaspal S.

AU - Koskinen, Seppo

AU - Kristiansson, Kati

AU - Kutalik, Zoltan

AU - Laan, Maris

AU - Larson, Marty

AU - Launer, Lenore J.

AU - Lehne, Benjamin

AU - Lehtimäki, Terho

AU - Liewald, David C.M.

AU - Lin, Li

AU - Lind, Lars

AU - Lindgren, Cecilia M.

AU - Liu, Yong Mei

AU - Loos, Ruth J.F.

AU - Lopez, Lorna M.

AU - Lu, Yingchang

AU - Lyytikäinen, Leo Pekka

AU - Mahajan, Anubha

AU - Mamasoula, Chrysovalanto

AU - Marrugat, Jaume

AU - Marten, Jonathan

AU - Milaneschi, Yuri

AU - Morgan, Anna

AU - Morris, Andrew P.

AU - Morrison, Alanna C.

AU - Munson, Peter J.

AU - Nalls, Mike A.

AU - Nandakumar, Priyanka

AU - Nelson, Christopher P.

AU - Niiranen, Teemu

AU - Nolte, Ilja M.

AU - Nutile, Teresa

AU - Oldehinkel, Albertine J.

AU - Oostra, Ben A.

AU - O’Reilly, Paul F.

AU - Org, Elin

AU - Padmanabhan, Sandosh

AU - Palmas, Walter

AU - Palotie, Aarno

AU - Pattie, Alison

AU - Penninx, Brenda W.J.H.

AU - Perola, Markus

AU - Peters, Annette

AU - Polasek, Ozren

AU - Pramstaller, Peter P.

AU - Nguyen, Quang Tri

AU - Raitakari, Olli T.

AU - Ren, Meixia

AU - Rettig, Rainer

AU - Rice, Kenneth

AU - Ridker, Paul M.

AU - Ried, Janina S.

AU - Riese, Harriëtte

AU - Ripatti, Samuli

AU - Robino, Antonietta

AU - Rose, Lynda M.

AU - Rotter, Jerome I.

AU - Rudan, Igor

AU - Ruggiero, Daniela

AU - Saba, Yasaman

AU - Sala, Cinzia F.

AU - Salomaa, Veikko

AU - Samani, Nilesh J.

AU - Sarin, Antti Pekka

AU - Schmidt, Reinhold

AU - Schmidt, Helena

AU - Shrine, Nick

AU - Siscovick, David

AU - Smith, Albert V.

AU - Snieder, Harold

AU - Sõber, Siim

AU - Sorice, Rossella

AU - Starr, John M.

AU - Stott, David J.

AU - Strachan, David P.

AU - Strawbridge, Rona J.

AU - Sundström, Johan

AU - Swertz, Morris A.

AU - Taylor, Kent D.

AU - Teumer, Alexander

AU - Tobin, Martin D.

AU - Tomaszewski, Maciej

AU - Toniolo, Daniela

AU - Traglia, Michela

AU - Trompet, Stella

AU - Tuomilehto, Jaakko

AU - Tzourio, Christophe

AU - Uitterlinden, André G.

AU - Vaez, Ahmad

AU - van der Most, Peter J.

AU - van Duijn, Cornelia M.

AU - Vergnaud, Anne Claire

AU - Verwoert, Germaine C.

AU - Vitart, Veronique

AU - Völker, Uwe

AU - Vollenweider, Peter

AU - Vuckovic, Dragana

AU - Watkins, Hugh

AU - Wild, Sarah H.

AU - Willemsen, Gonneke

AU - Wilson, James F.

AU - Wright, Alan F.

AU - Yao, Jie

AU - Zemunik, Tatijana

AU - Zhang, Weihua

AU - Attia, John R.

AU - Butterworth, Adam S.

AU - Chasman, Daniel I.

AU - Conen, David

AU - Cucca, Francesco

AU - Danesh, John

PY - 2018/10/1

Y1 - 2018/10/1

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

UR - http://www.scopus.com/inward/record.url?scp=85053701561&partnerID=8YFLogxK

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Review article

C2 - 30224653

AN - SCOPUS:85053701561

SN - 1061-4036

VL - 50

SP - 1412

EP - 1425

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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