Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence

Daoshan Zheng, Sarah A. McLaughlin, Klaus H. Kaestner, Zhaoyu Li

Research output: Contribution to journalArticle

Abstract

Risk reducing mastectomy is the only surgical approach for the prevention of breast cancer in women with deleterious genetic mutations or in those deemed to be at extremely high risk. However, up to 10.5% of these women still developed breast cancer. Thus, developing new strategies for complete prevention of breast cancer is imperative. Mammary ducts were ablated by mammary-specific ablation of forkhead box protein A1 (Foxa1). Mammary tumorigenesis was induced in control and mammary-specific Foxa1 knockout mice using carcinogens. No mammary tumors were observed in these knockout mice compared to four types of breast tumors induced in control mice. We present a promising novel strategy for the prevention of breast cancer by genetic ablation of mammary ducts via targeting Foxa1.

Original languageEnglish
Pages (from-to)424-428
Number of pages5
JournalAmerican Journal of Cancer Research
Volume9
Issue number2
Publication statusPublished - 2019
Externally publishedYes

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