TY - JOUR
T1 - Genesis of the frog retinal pigment epithelium
AU - Beazley, Lyn
AU - Dunlop, S.A.
AU - Tennant, Marc
AU - Tomlin, T.L.
AU - Preuss, J.M.
AU - Coleman, Sarah
PY - 1996
Y1 - 1996
N2 - To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [H-3]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [H-3]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
AB - To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [H-3]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [H-3]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
U2 - 10.1016/0165-3806(96)00125-3
DO - 10.1016/0165-3806(96)00125-3
M3 - Article
VL - 96
SP - 290
EP - 294
JO - Developmental Brain Research
JF - Developmental Brain Research
ER -