Genesis of the frog retinal pigment epithelium

Lyn Beazley, S.A. Dunlop, Marc Tennant, T.L. Tomlin, J.M. Preuss, Sarah Coleman

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [H-3]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [H-3]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
Original languageEnglish
Pages (from-to)290-294
JournalDevelopmental Brain Research
Volume96
DOIs
Publication statusPublished - 1996

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