Projects per year
Abstract
Two human iPSC lines were generated from dermal fibroblasts derived from a patient with retinitis pigmentosa caused by CRB1 mutation using episomal plasmids containing OCT4, SOX2, LIN28, KLF4, L-MYC and mp53DD. These clonal iPSC lines carry compound heterozygous mutations in CRB1 (c.2555 T > C and c.3014A > T). Both lines expressed pluripotency markers, displayed a normal karyotype and demonstrated the ability to differentiate into the three primary germ layers, as well as retinal organoids.
Original language | English |
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Article number | 102403 |
Journal | Stem Cell Research |
Volume | 54 |
DOIs | |
Publication status | Published - Jul 2021 |
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Dive into the research topics of 'Generation of two induced pluripotent stem cell lines from a retinitis pigmentosa patient with compound heterozygous mutations in CRB1'. Together they form a unique fingerprint.Projects
- 1 Finished
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MRFF - Developing Personalised Treatment for Retinal Degeneration
Chen, F. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/18 → 31/12/21
Project: Research
Research output
- 5 Citations
- 1 Doctoral Thesis
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Investigating the pathogenic mechanisms of inherited retinal diseases: an in vitro- and CRISPR-based approach
Moon, S. Y., 2022, (Unpublished)Research output: Thesis › Doctoral Thesis
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