Projects per year
Abstract
We report the generation of the iPSC line LEIi005-B from a patient with retinitis pigmentosa caused by a dominant nonsense mutation in the RP1 gene (c.2098G>T p.E700X). Reprogramming of dermal fibroblasts was performed using episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, mir302/367 microRNA and shRNA for p53 to establish the clonal iPSC line LEIi005-B. LEIi005-B expressed pluripotent stem cell markers, had a normal karyotype and differentiated into endoderm, mesoderm and ectoderm.
Original language | English |
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Article number | 101452 |
Journal | Stem Cell Research |
Volume | 37 |
DOIs | |
Publication status | Published - 1 May 2019 |
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Dive into the research topics of 'Generation of an induced pluripotent stem cell line from a patient with retinitis pigmentosa caused by RP1 mutation'. Together they form a unique fingerprint.Projects
- 2 Finished
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MRFF - Developing Personalised Treatment for Retinal Degeneration
Chen, F. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/18 → 31/12/21
Project: Research
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From discovery to therapy in genetic eye diseases
Mackey, D. (Investigator 01), Craig, J. (Investigator 02), Hewitt, A. (Investigator 03), Burdon, K. (Investigator 04), Jamieson, R. (Investigator 05), Grigg, J. (Investigator 06), MacGregor, S. (Investigator 07), Chen, F. (Investigator 08), Otlowski, M. (Investigator 09) & Schofield, D. (Investigator 10)
NHMRC National Health and Medical Research Council
1/01/16 → 31/12/20
Project: Research
Research output
- 1 Citations
- 1 Doctoral Thesis
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Investigating the pathogenic mechanisms of inherited retinal diseases: an in vitro- and CRISPR-based approach
Moon, S. Y., 2022, (Unpublished)Research output: Thesis › Doctoral Thesis
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