The Collaborative Cross (CC) is a purpose-built community resource with the aim to improve our knowledge and understanding of human diseases. The principal aims of this project are to investigate the dental and skeletal fields of the CC and to identify novel molecular determinants of their related disease. The Gene Mine CC population fields were screened using X-ray and micro-CT. A novel hypodontia phenotype of mouse was discovered, for which candidate genes with single nucleotide polymorphisms were identified using quantitative trait loci mapping. Additionally, diagnostic genetic testing of a rare human clinical case was performed using next generation sequencing.
|Qualification||Doctor of Philosophy|
|Award date||17 Jan 2022|
|Publication status||Unpublished - 2022|