Gene Expression: the Key to Understanding HIV-1 Infection?

Melinda Judge, Erica Parker, Denise Naniche, Peter Le Souëf

Research output: Contribution to journalReview articlepeer-review

4 Citations (Web of Science)


SUMMARYGene expression profiling of the host response to HIV infection has promised to fill the gaps in our knowledge and provide new insights toward vaccine and cure. However, despite 20 years of research, the biggest questions remained unanswered. A literature review identified 62 studies examining gene expression dysregulation in samples from individuals living with HIV. Changes in gene expression were dependent on cell/tissue type, stage of infection, viremia, and treatment status. Some cell types, notably CD4+ T cells, exhibit upregulation of cell cycle, interferon-related, and apoptosis genes consistent with depletion. Others, including CD8+ T cells and natural killer cells, exhibit perturbed function in the absence of direct infection with HIV. Dysregulation is greatest during acute infection. Differences in study design and data reporting limit comparability of existing research and do not as yet provide a coherent overview of gene expression in HIV. This review outlines the extraordinarily complex host response to HIV and offers recommendations to realize the full potential of HIV host transcriptomics.

Original languageEnglish
JournalMicrobiology and molecular biology reviews : MMBR
Issue number2
Publication statusPublished - 20 May 2020


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