GC-MS analysis of lipid oxidation products in blood, urine, and tissue samples

Research output: Chapter in Book/Conference paperChapter

3 Citations (Scopus)

Abstract

Oxidant stress has been identified as important in the pathology of many diseases. Oxidation products of polyunsaturated fatty acids collectively termed isoprostanes, neuroprostanes, and isofurans are considered the most reliable measures of in vivo lipid oxidation, and they are widely used to assess oxidant stress in various diseases. Here we describe the measurement of these lipid oxidation products using gas chromatography mass spectrometry with electron capture negative ionization.

Original languageEnglish
Title of host publicationClinical Metabolomics
Subtitle of host publicationMethods and Protocols
EditorsMartin Giera
PublisherHumana Press
Pages283-292
Number of pages10
Volume1730
ISBN (Electronic)9781493975921
ISBN (Print)9781493975914
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameMethods in Molecular Biology
Volume1730
ISSN (Print)1064-3745

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  • Cite this

    Barden, A., & Mori, T. A. (2018). GC-MS analysis of lipid oxidation products in blood, urine, and tissue samples. In M. Giera (Ed.), Clinical Metabolomics: Methods and Protocols (Vol. 1730, pp. 283-292). (Methods in Molecular Biology; Vol. 1730). Humana Press. https://doi.org/10.1007/978-1-4939-7592-1_21