Gastro-oesophageal reflux and respiratory symptoms in Busselton adults: the affects of body weight and sleep apnoea

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Abstract

Background/Aim:  Respiratory symptoms and gastro-oesophageal reflux disease (GORD) are common within the general population. Although a number of epidemiological studies have addressed their relationship, none has investigated the confounding effects of body mass index (BMI) and obstructive sleep apnoea (OSA), both of which are associated with reflux. Methods:  Men and women (2700) from the 2005–2007 cross-sectional Busselton health survey were included. Questionnaire data included demography, information on general health, asthma, cough, wheeze, dyspnoea and reflux symptoms (never, monthly or less often and weekly or more often). BMI, risk of OSA (Berlin questionnaire definition), spirometry and airway hyperresponsiveness (AHR) were recorded. The effects of BMI and OSA on the relationship between respiratory and reflux symptoms were examined using logistic regression models, expressed as adjusted odds ratios for risk of respiratory symptoms by reflux symptom category. Results:  Fifty per cent had reflux symptoms (5–10% weekly or more often). Reflux symptoms had strong positive, dose-related associations with cough/phlegm, breathlessness, chest tightness and wheeze in the last 12 months (P < 0.001), but were not related to diagnosed asthma or AHR. Twenty-three per cent were at high risk of OSA and 63% had a BMI of >25 (22% > 30). Increased weight or high risk of OSA did not affect the relationship between respiratory symptoms and reflux symptoms. Conclusion:  The relationship between reflux and respiratory symptoms was independent of BMI, high risk of OSA or AHR. These findings suggest that reflux contributes directly to respiratory symptoms.
Original languageEnglish
Pages (from-to)772–779
JournalInternal Medicine Journal
Volume42
Issue number7
DOIs
Publication statusPublished - 2012

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Sleep Apnea Syndromes
Obstructive Sleep Apnea
Gastroesophageal Reflux
Body Weight
Body Mass Index
Cough
Dyspnea
Logistic Models
Esophageal Diseases
Spirometry
Berlin
Health Surveys
Epidemiologic Studies
Thorax
Asthma
Odds Ratio
Demography
Weights and Measures
Health
Population

Cite this

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title = "Gastro-oesophageal reflux and respiratory symptoms in Busselton adults: the affects of body weight and sleep apnoea",
abstract = "Background/Aim:  Respiratory symptoms and gastro-oesophageal reflux disease (GORD) are common within the general population. Although a number of epidemiological studies have addressed their relationship, none has investigated the confounding effects of body mass index (BMI) and obstructive sleep apnoea (OSA), both of which are associated with reflux. Methods:  Men and women (2700) from the 2005–2007 cross-sectional Busselton health survey were included. Questionnaire data included demography, information on general health, asthma, cough, wheeze, dyspnoea and reflux symptoms (never, monthly or less often and weekly or more often). BMI, risk of OSA (Berlin questionnaire definition), spirometry and airway hyperresponsiveness (AHR) were recorded. The effects of BMI and OSA on the relationship between respiratory and reflux symptoms were examined using logistic regression models, expressed as adjusted odds ratios for risk of respiratory symptoms by reflux symptom category. Results:  Fifty per cent had reflux symptoms (5–10{\%} weekly or more often). Reflux symptoms had strong positive, dose-related associations with cough/phlegm, breathlessness, chest tightness and wheeze in the last 12 months (P < 0.001), but were not related to diagnosed asthma or AHR. Twenty-three per cent were at high risk of OSA and 63{\%} had a BMI of >25 (22{\%} > 30). Increased weight or high risk of OSA did not affect the relationship between respiratory symptoms and reflux symptoms. Conclusion:  The relationship between reflux and respiratory symptoms was independent of BMI, high risk of OSA or AHR. These findings suggest that reflux contributes directly to respiratory symptoms.",
author = "Siobhain Mulrennan and Matthew Knuiman and Mark Divitini and DJ Cullen and Michael Hunter and Jennie Hui and Arthur Musk and Alan James",
year = "2012",
doi = "10.1111/j.1445-5994.2011.02535.x",
language = "English",
volume = "42",
pages = "772–779",
journal = "Internal Medicine Journal (Print)",
issn = "1444-0903",
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number = "7",

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TY - JOUR

T1 - Gastro-oesophageal reflux and respiratory symptoms in Busselton adults: the affects of body weight and sleep apnoea

AU - Mulrennan, Siobhain

AU - Knuiman, Matthew

AU - Divitini, Mark

AU - Cullen, DJ

AU - Hunter, Michael

AU - Hui, Jennie

AU - Musk, Arthur

AU - James, Alan

PY - 2012

Y1 - 2012

N2 - Background/Aim:  Respiratory symptoms and gastro-oesophageal reflux disease (GORD) are common within the general population. Although a number of epidemiological studies have addressed their relationship, none has investigated the confounding effects of body mass index (BMI) and obstructive sleep apnoea (OSA), both of which are associated with reflux. Methods:  Men and women (2700) from the 2005–2007 cross-sectional Busselton health survey were included. Questionnaire data included demography, information on general health, asthma, cough, wheeze, dyspnoea and reflux symptoms (never, monthly or less often and weekly or more often). BMI, risk of OSA (Berlin questionnaire definition), spirometry and airway hyperresponsiveness (AHR) were recorded. The effects of BMI and OSA on the relationship between respiratory and reflux symptoms were examined using logistic regression models, expressed as adjusted odds ratios for risk of respiratory symptoms by reflux symptom category. Results:  Fifty per cent had reflux symptoms (5–10% weekly or more often). Reflux symptoms had strong positive, dose-related associations with cough/phlegm, breathlessness, chest tightness and wheeze in the last 12 months (P < 0.001), but were not related to diagnosed asthma or AHR. Twenty-three per cent were at high risk of OSA and 63% had a BMI of >25 (22% > 30). Increased weight or high risk of OSA did not affect the relationship between respiratory symptoms and reflux symptoms. Conclusion:  The relationship between reflux and respiratory symptoms was independent of BMI, high risk of OSA or AHR. These findings suggest that reflux contributes directly to respiratory symptoms.

AB - Background/Aim:  Respiratory symptoms and gastro-oesophageal reflux disease (GORD) are common within the general population. Although a number of epidemiological studies have addressed their relationship, none has investigated the confounding effects of body mass index (BMI) and obstructive sleep apnoea (OSA), both of which are associated with reflux. Methods:  Men and women (2700) from the 2005–2007 cross-sectional Busselton health survey were included. Questionnaire data included demography, information on general health, asthma, cough, wheeze, dyspnoea and reflux symptoms (never, monthly or less often and weekly or more often). BMI, risk of OSA (Berlin questionnaire definition), spirometry and airway hyperresponsiveness (AHR) were recorded. The effects of BMI and OSA on the relationship between respiratory and reflux symptoms were examined using logistic regression models, expressed as adjusted odds ratios for risk of respiratory symptoms by reflux symptom category. Results:  Fifty per cent had reflux symptoms (5–10% weekly or more often). Reflux symptoms had strong positive, dose-related associations with cough/phlegm, breathlessness, chest tightness and wheeze in the last 12 months (P < 0.001), but were not related to diagnosed asthma or AHR. Twenty-three per cent were at high risk of OSA and 63% had a BMI of >25 (22% > 30). Increased weight or high risk of OSA did not affect the relationship between respiratory symptoms and reflux symptoms. Conclusion:  The relationship between reflux and respiratory symptoms was independent of BMI, high risk of OSA or AHR. These findings suggest that reflux contributes directly to respiratory symptoms.

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DO - 10.1111/j.1445-5994.2011.02535.x

M3 - Article

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EP - 779

JO - Internal Medicine Journal (Print)

JF - Internal Medicine Journal (Print)

SN - 1444-0903

IS - 7

ER -