Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy

Stephan Karl; Moses Laman; Brioni Moore; J. Benjamin; T. Koleala; C. Ibam; B. Kasian; P.M. Siba; A. Waltmann; I. Mueller; Rob Woodward; Tim St. Pierre; Timothy Davis

doi:10.1128/AAC.00136-15

Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy

Stephan Karl, Moses Laman, Brioni Moore, J. Benjamin, T. Koleala, C. Ibam, B. Kasian, P.M. Siba, A. Waltmann, I. Mueller, Rob Woodward, Tim St. Pierre, Timothy Davis

Research output: Contribution to journal › Article › peer-review

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Abstract

Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated Plasmodium falciparum and/or Plasmodium vivax malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral P. falciparum gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61/μl for artemisinin-naphthoquine (P <0.001). The median time for P. falciparum gametocyte density to fall to

Original language	English
Pages (from-to)	4489-4496
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00136-15
Publication status	Published - Aug 2015

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10.1128/AAC.00136-15

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Karl, S., Laman, M., Moore, B., Benjamin, J., Koleala, T., Ibam, C., Kasian, B., Siba, P. M., Waltmann, A., Mueller, I., Woodward, R., St. Pierre, T., & Davis, T. (2015). Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy. Antimicrobial Agents and Chemotherapy, 59(8), 4489-4496. https://doi.org/10.1128/AAC.00136-15

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title = "Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy",

abstract = "Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated Plasmodium falciparum and/or Plasmodium vivax malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral P. falciparum gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61/μl for artemisinin-naphthoquine (P <0.001). The median time for P. falciparum gametocyte density to fall to",

author = "Stephan Karl and Moses Laman and Brioni Moore and J. Benjamin and T. Koleala and C. Ibam and B. Kasian and P.M. Siba and A. Waltmann and I. Mueller and Rob Woodward and \{St. Pierre\}, Tim and Timothy Davis",

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Karl, S, Laman, M, Moore, B, Benjamin, J, Koleala, T, Ibam, C, Kasian, B, Siba, PM, Waltmann, A, Mueller, I, Woodward, R, St. Pierre, T & Davis, T 2015, 'Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy', Antimicrobial Agents and Chemotherapy, vol. 59, no. 8, pp. 4489-4496. https://doi.org/10.1128/AAC.00136-15

Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy. / Karl, Stephan; Laman, Moses; Moore, Brioni et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 8, 08.2015, p. 4489-4496.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy

AU - Karl, Stephan

AU - Laman, Moses

AU - Moore, Brioni

AU - Benjamin, J.

AU - Koleala, T.

AU - Ibam, C.

AU - Kasian, B.

AU - Siba, P.M.

AU - Waltmann, A.

AU - Mueller, I.

AU - Woodward, Rob

AU - St. Pierre, Tim

AU - Davis, Timothy

PY - 2015/8

Y1 - 2015/8

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AB - Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated Plasmodium falciparum and/or Plasmodium vivax malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral P. falciparum gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61/μl for artemisinin-naphthoquine (P <0.001). The median time for P. falciparum gametocyte density to fall to

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DO - 10.1128/AAC.00136-15

M3 - Article

SN - 0066-4804

VL - 59

SP - 4489

EP - 4496

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy

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