Gametocyte clearance kinetics determined by quantitative magnetic fractionation in Melanesian children with uncomplicated malaria treated with artemisinin combination therapy

Stephan Karl, Moses Laman, Brioni Moore, J. Benjamin, T. Koleala, C. Ibam, B. Kasian, P.M. Siba, A. Waltmann, I. Mueller, Rob Woodward, Tim St. Pierre, Timothy Davis

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    Abstract

    Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated Plasmodium falciparum and/or Plasmodium vivax malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral P. falciparum gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61/μl for artemisinin-naphthoquine (P <0.001). The median time for P. falciparum gametocyte density to fall to
    Original languageEnglish
    Pages (from-to)4489-4496
    JournalAntimicrobial Agents and Chemotherapy
    Volume59
    Issue number8
    DOIs
    Publication statusPublished - Aug 2015

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