Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Mitchell Hattie; T. Ito; Aleksandra Debowski; T. Arakawa; T. Katayama; K. Yamamoto; S. Fushinobu; Keith Stubbs

doi:10.1039/c5cc05494j

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Mitchell Hattie, T. Ito, Aleksandra Debowski, T. Arakawa, T. Katayama, K. Yamamoto, S. Fushinobu, Keith Stubbs

School of Molecular Sciences

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Abstract

The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.

Original language	English
Pages (from-to)	15008-15011
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	81
Early online date	27 Aug 2015
DOIs	https://doi.org/10.1039/c5cc05494j
Publication status	Published - 18 Oct 2015

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10.1039/c5cc05494jLicence: CC BY-NC

Hattie et al 2015 Gaining insight into the catalysisFinal published version, 1.62 MBLicence: CC BY-NC

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title = "Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis",

abstract = "The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.",

author = "Mitchell Hattie and T. Ito and Aleksandra Debowski and T. Arakawa and T. Katayama and K. Yamamoto and S. Fushinobu and Keith Stubbs",

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T1 - Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

AU - Hattie, Mitchell

AU - Ito, T.

AU - Debowski, Aleksandra

AU - Arakawa, T.

AU - Katayama, T.

AU - Yamamoto, K.

AU - Fushinobu, S.

AU - Stubbs, Keith

PY - 2015/10/18

Y1 - 2015/10/18

N2 - The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.

AB - The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described.

UR - https://www.scopus.com/pages/publications/84942903534

U2 - 10.1039/c5cc05494j

DO - 10.1039/c5cc05494j

M3 - Article

C2 - 26312778

SN - 1359-7345

VL - 51

SP - 15008

EP - 15011

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Abstract

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