Gadolinium-DOTA enhanced MR imaging of intracranial lesions

Paul M. Parizel, Hendrik R. Degryse, Jan Gheuens, Jean Jacques Martin, Michel Van Vyve, Christian De La Porte, Paul Selosse, Paul Van De Heyning, Arthur M. De Schepper

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Gadolinium 1,4,7,10-tetraazacyclododecane-N, Nʹ, Nʺ, N‴-tetraacetic acid (Gd-DOTA) is the first of a new class of macrocyclic paramagnetic magnetic resonance (MR) contrast agents (gadolinium cryptelates) to be used in clinical practice. Gadolinium-DOTA possesses relaxation properties similar to those of gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). We report our initial clinical experience in 38 patients with intracranial lesions studied with MR before and after injection of Gd-DOTA. Diseases included primary and metastatic brain tumor, cerebral infarct, vascular malformation, meningioma, hemangiopericytoma, schwannoma, and pituitary macroadenoma. Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight. All studies were performed on a superconductive 0.5 T system. As compared to noncontrast T1- and T2-weighted images (WI), Gd-DOTA enhanced T1 WI were useful in defining the anatomy of malignant intraaxial tumors (high-grade glioma, metastasis) and in tumor versus edema differentiation. Low-grade gliomas did not enhance; in these cases the precontrast T2-weighted sequence was found to be more informative. In post-operative patients, Gd-DOTA allowed us to demonstrate residual tumor or tumor recurrence. Extraaxial tumors (meningioma, hemangiopericytoma, neu-roma) enhanced markedly, presumably reflecting tumor vascularity. In our experience, the use of Gd-DOTA improves the anatomic definition of cerebral lesions and in some cases increases both MR sensitivity and specificity. We found Gd-DOTA to be a well tolerated and effective paramagnetic contrast agent. Gadolinium-DOTA can be considered as an alternative water-soluble MR contrast agent to Gd-DTPA.

Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalJournal of Computer Assisted Tomography
Issue number3
Publication statusPublished - 1 Jan 1989
Externally publishedYes


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