FXYD5 is a marker for poor prognosis and a potential driver for metastasis in ovarian carcinomas

Pichai Raman, Timothy Purwin, Richard Pestell, Aydin Tozeren

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Ovarian cancer (OC) is a leading cause of cancer mortality, but aside from a few well-studied mutations, very little is known about its underlying causes. As such, we performed survival analysis on ovarian copy number amplifications and gene expression datasets presented by The Cancer Genome Atlas in order to identify potential drivers and markers of aggressive OC. Additionally, two independent datasets from the Gene Expression Omnibus web platform were used to validate the identified markers. Based on our analysis, we identified FXYD5, a glycoprotein known to reduce cell adhesion, as a potential driver of metastasis and a significant predictor of mortality in OC. As a marker of poor outcome, the protein has effective antibodies against it for use in tissue arrays. FXYD5 bridges together a wide variety of cancers, including ovarian, breast cancer stage II, thyroid, colorectal, pancreatic, and head and neck cancers for metastasis studies.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalCancer Informatics
Volume14
DOIs
Publication statusPublished - 12 Oct 2015
Externally publishedYes

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