TY - JOUR
T1 - Further characterization of MHC haplotypes demonstrates conservation telomeric of HLA-A: update of the 4AOH and 10IHW cell panels
AU - Cattley, S.K.
AU - Williamson, J.F.
AU - Tay, Guan
AU - Martinez, Olga
AU - Gaudieri, Silvana
AU - Dawkins, R.L.
PY - 2000
Y1 - 2000
N2 - Cell panels have been used extensively ill studies of polymorphism and disease associations within the major histocompatibility complex (MHC), but the results from these panels require continuous updates with the increasing availability of novel data. We present here an updated table of the typings of the 10IHW and 4AOH panels. Local data included are HFE, HERV-K(CI) and six microsatellites telomeric of HLA-A. Typings for class I, MICA (PERB11.1), MICE (PERB11.2), XA, XB, LMP2 and 10 microsatellites reported by others have also been consolidated in this table. The tabulation shows that the length of conservation in the human MHC is even more extensive than previously thought. Human MHC ancestral haplotypes are inherited as a conserved region of genomic sequence spanning some 6-8 megabases from the HLA class II region and beyond the HLA class I region up to and including the HFE gene. Numerous examples of historical recombinations were also observed.
AB - Cell panels have been used extensively ill studies of polymorphism and disease associations within the major histocompatibility complex (MHC), but the results from these panels require continuous updates with the increasing availability of novel data. We present here an updated table of the typings of the 10IHW and 4AOH panels. Local data included are HFE, HERV-K(CI) and six microsatellites telomeric of HLA-A. Typings for class I, MICA (PERB11.1), MICE (PERB11.2), XA, XB, LMP2 and 10 microsatellites reported by others have also been consolidated in this table. The tabulation shows that the length of conservation in the human MHC is even more extensive than previously thought. Human MHC ancestral haplotypes are inherited as a conserved region of genomic sequence spanning some 6-8 megabases from the HLA class II region and beyond the HLA class I region up to and including the HFE gene. Numerous examples of historical recombinations were also observed.
U2 - 10.1046/j.1365-2370.2000.00226.x
DO - 10.1046/j.1365-2370.2000.00226.x
M3 - Article
VL - 27
SP - 397
EP - 426
JO - European Journal of Immunogenetics
JF - European Journal of Immunogenetics
SN - 0960-7420
ER -