Fungal Polyketide-Nonribosomal Peptide Synthetases and Their Associated Natural Products

Hang Li, Thomas Booth, Yit-Heng Chooi

Research output: Chapter in Book/Conference paperChapterpeer-review

Abstract

Fungal hybrid polyketide synthase-nonribosomal peptide synthetases (PKS-NRPSs) significantly expand the diversity and functionalities of polyketide metabolites by fusing diverse polyketide backbones with a range of amino acids of different chemical properties. This gives rise to a plethora of polyketide acyl-aminoacyl chains that are further diversified by the mechanism of release and post-PKS-NRPS processing. Using selected examples from biosynthetic studies, this article provides an overview of the fungal PKS-NRPS biosynthetic logic, with emphasis on the strategies that introduce structural diversity and complexity to PKS-NRPS products. We have divided the common strategies into: (1) variations in polyketide branching and functional group modifications, (2) selection and incorporation of amino acids, (3) release mechanisms, and (4) post-PKS-NRPS cyclization/rearrangement of the polyketide-amino acid backbone. The prospects and challenges of engineering fungal PKS-NRPS hybrids are also discussed.
Original languageEnglish
Title of host publicationComprehensive Natural Products III
Subtitle of host publicationChemistry and Biology
EditorsHung-Wen (Ben) Liu, Tadhg P. Begley
PublisherElsevier
Pages415-444
Volume1
Edition3
ISBN (Print)978-0-08-102691-5
DOIs
Publication statusPublished - 2020

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