Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

Joanne Hendrini Van Vuuren

    Research output: ThesisDoctoral Thesis

    280 Downloads (Pure)

    Abstract

    The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells but
    also implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented In
    this thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth and
    proliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important In
    maintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35
    influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Winteringham, Louise, Supervisor
    • Yeoh, George, Supervisor
    • Klinken, Peter, Supervisor
    Award date15 Feb 2018
    DOIs
    Publication statusUnpublished - 2018

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