Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

Joanne Hendrini Van Vuuren

    Research output: ThesisDoctoral Thesis

    Abstract

    The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells but
    also implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented In
    this thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth and
    proliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important In
    maintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35
    influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.
    LanguageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Winteringham, Louise, Supervisor
    • Yeoh, George, Supervisor
    • Klinken, Svend, Supervisor
    Award date15 Feb 2018
    DOIs
    StateUnpublished - 2018

    Fingerprint

    Liver Neoplasms
    Homeostasis
    Inflammation
    Ubiquitin-Protein Ligases
    Liver
    Knockout Mice
    Liver Cirrhosis
    Neoplasms
    Carcinogenesis
    Stem Cells
    Obesity
    Biomarkers
    Growth

    Cite this

    @phdthesis{569b4f9d2da342aab25372649bebf878,
    title = "Functional significance of TRIM35 In haematopoietic and hepatic homeostasis",
    abstract = "The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells butalso implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented Inthis thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth andproliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important Inmaintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.",
    keywords = "TRIM proteins, ubiquitination, TGF-b signaling, Haematopoietic stem cells, Hepatocellular carcinoma, inflammation",
    author = "{Van Vuuren}, {Joanne Hendrini}",
    year = "2018",
    doi = "10.4225/23/5aa0880306eae",
    language = "English",
    school = "The University of Western Australia",

    }

    Van Vuuren, JH 2018, 'Functional significance of TRIM35 In haematopoietic and hepatic homeostasis', Doctor of Philosophy, The University of Western Australia. DOI: 10.4225/23/5aa0880306eae

    Functional significance of TRIM35 In haematopoietic and hepatic homeostasis. / Van Vuuren, Joanne Hendrini.

    2018.

    Research output: ThesisDoctoral Thesis

    TY - THES

    T1 - Functional significance of TRIM35 In haematopoietic and hepatic homeostasis

    AU - Van Vuuren,Joanne Hendrini

    PY - 2018

    Y1 - 2018

    N2 - The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells butalso implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented Inthis thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth andproliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important Inmaintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.

    AB - The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells butalso implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented Inthis thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth andproliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important Inmaintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.

    KW - TRIM proteins

    KW - ubiquitination

    KW - TGF-b signaling

    KW - Haematopoietic stem cells

    KW - Hepatocellular carcinoma

    KW - inflammation

    U2 - 10.4225/23/5aa0880306eae

    DO - 10.4225/23/5aa0880306eae

    M3 - Doctoral Thesis

    ER -