Abstract
The tumour suppressor, TRIM35, is an E3 ubiquitin ligase initially Identified for Its role in regulating haemopoietic cells but
also implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented In
this thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth and
proliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important In
maintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35
influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.
also implicated in Inflammation and metabolism and recently identified as a key biomarker for liver cancer. Data presented In
this thesis show that TRIM35 can regulate several components of the TGFbsignaling pathway, important In cell growth and
proliferation and often deregulated in cancer. A TRIM35 knockout mouse model demonstrated that TRIM35 is important In
maintaining homeostasis within the haemopoielic stem cell compartment and, In the context of oncogenesis, deleting TRIM35
influenced obesity, Inflammation and liver fibrosis, key precursors to liver cancer.
| Original language | English |
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| Qualification | Doctor of Philosophy |
| Awarding Institution |
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| Supervisors/Advisors |
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| Award date | 15 Feb 2018 |
| DOIs | |
| Publication status | Unpublished - 2018 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - VAN VUUREN Joanne Hendrini - 2018
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