Functional significance of dendritic swelling after loud sounds in the guinea pig cochlea

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Abstract

Exposure of the guinea pig cochlea to loud pure tones caused a dramatic swelling of afferent dendrites beneath the inner hair cell (IHC). This swelling occurred in a restricted region of the cochlea basalward of the exposure frequency location. For a 110 dB tone swelling wasjust detectable in 1 μm sections for a 18, min exposure and was clearly visible after a 22 1 2 min exposure. Swelling was reversible. Exposures which caused swelling produced a loss in sensitivity of the flat low frequency 'tail' of the frequency-threshold curves of single auditory neurons whose most sensitive frequency was a 1 2 octave higher than the exposure frequency. The findings are consistent with the notion that dendritic swelling causes a non-selective decrease in sensitivity to all frequencies of sound.

Original languageEnglish
Pages (from-to)263-278
Number of pages16
JournalHearing Research
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Jan 1983

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