TY - JOUR
T1 - Functional respiratory imaging as a tool to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis
AU - Van Holsbeke, Cedric S.
AU - Leemans, Glenn
AU - Vos, Wim G.
AU - De Backer, Jan W.
AU - Vinchurkar, Samir C.
AU - Geldof, Michel
AU - Verdonck, Pascal R.
AU - Parizel, Paul M.
AU - Van Schil, Paul E.
AU - De Backer, Wilfried A.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - A completely different treatment approach was chosen for 2 patients with unilateral diaphragmatic paralysis and complaints of dyspnea despite similar anatomic and physiologic abnormalities. These decisions were supported by results obtained by functional respiratory imaging (FRI). FRI generated functional information on lobar ventilation and local drug deposition. In the first patient, some lobes were poorly ventilated, and drug deposition simulation showed that some regions were undertreated. This patient underwent diaphragmatic plication to restore ventilation. In the second patient, all lobes were still ventilated. A conservative approach with regular follow-ups was chosen to wait for spontaneous recovery of the diaphragmatic function. Both patients improved subjectively and objectively. These cases demonstrate how novel medical imaging techniques such as FRI can be used to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis.
AB - A completely different treatment approach was chosen for 2 patients with unilateral diaphragmatic paralysis and complaints of dyspnea despite similar anatomic and physiologic abnormalities. These decisions were supported by results obtained by functional respiratory imaging (FRI). FRI generated functional information on lobar ventilation and local drug deposition. In the first patient, some lobes were poorly ventilated, and drug deposition simulation showed that some regions were undertreated. This patient underwent diaphragmatic plication to restore ventilation. In the second patient, all lobes were still ventilated. A conservative approach with regular follow-ups was chosen to wait for spontaneous recovery of the diaphragmatic function. Both patients improved subjectively and objectively. These cases demonstrate how novel medical imaging techniques such as FRI can be used to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis.
KW - computer-assisted decision making
KW - diaphragmatic paralysis
KW - MeSH
KW - personalized medicine
KW - pulmonary ventilation
KW - respiratory drug administration
KW - thoracic surgery
UR - http://www.scopus.com/inward/record.url?scp=84943371761&partnerID=8YFLogxK
U2 - 10.4187/respcare.02756
DO - 10.4187/respcare.02756
M3 - Short survey
C2 - 24327746
AN - SCOPUS:84943371761
VL - 59
SP - e127-e131
JO - Respiratory Care: a monthly science journal
JF - Respiratory Care: a monthly science journal
SN - 0020-1324
IS - 9
ER -