TY - JOUR
T1 - Functional magnetic resonance imaging evaluation of lumbosacral radiculopathic pain
AU - Koefman, A.J.
AU - Licari, Melissa
AU - Bynevelt, M.
AU - Lind, Christopher
PY - 2016
Y1 - 2016
N2 - ©AANS, 2016.OBJECTIVE: An objective biomarker for pain is yet to be established. Functional MRI (fMRI) is a promising neuroimaging technique that may reveal an objective radiological biomarker. The purpose of this study was to evaluate fMRI technology in the setting of lumbosacral radiculopathy and discuss its application in revealing a biomarker for pain in the future. METHODS: A prospective, within-participant control study was conducted. Twenty participants with painful lumbosacral radiculopathy from intervertebral disc pathology were recruited. Functional imaging of the brain was performed during a randomly generated series of nonprovocative and provocative straight leg raise maneuvers. RESULTS: With a statistical threshold set at p <0.000001, 3 areas showed significant blood oxygen level-dependent (BOLD) signal change: right superior frontal gyrus (x = 2, y = 13, z = 48, k = 29, Brodmann area 6 [BA6]), left supramarginal cortex (x = -37, y = -44, z = 33, k = 1084, BA40), and left parietal cortex (x = -19, y = -41, z = 63, k = 354, BA5).With a statistical threshold set at p <0.0002, 2 structures showed significant BOLD signal change: right putamen (x = 29, y = -11, z = 6, k = 72) and bilateral thalami (right: x = 23, y = -11, z = 21, k = 29; x = 8, y = -11, z = 9, k = 274; and left: x = -28, y = -32, z = 6, k = 21). CONCLUSIONS: The results in this study compare with those in previous studies and suggest that fMRI technology can provide an objective assessment of the pain experience.
AB - ©AANS, 2016.OBJECTIVE: An objective biomarker for pain is yet to be established. Functional MRI (fMRI) is a promising neuroimaging technique that may reveal an objective radiological biomarker. The purpose of this study was to evaluate fMRI technology in the setting of lumbosacral radiculopathy and discuss its application in revealing a biomarker for pain in the future. METHODS: A prospective, within-participant control study was conducted. Twenty participants with painful lumbosacral radiculopathy from intervertebral disc pathology were recruited. Functional imaging of the brain was performed during a randomly generated series of nonprovocative and provocative straight leg raise maneuvers. RESULTS: With a statistical threshold set at p <0.000001, 3 areas showed significant blood oxygen level-dependent (BOLD) signal change: right superior frontal gyrus (x = 2, y = 13, z = 48, k = 29, Brodmann area 6 [BA6]), left supramarginal cortex (x = -37, y = -44, z = 33, k = 1084, BA40), and left parietal cortex (x = -19, y = -41, z = 63, k = 354, BA5).With a statistical threshold set at p <0.0002, 2 structures showed significant BOLD signal change: right putamen (x = 29, y = -11, z = 6, k = 72) and bilateral thalami (right: x = 23, y = -11, z = 21, k = 29; x = 8, y = -11, z = 9, k = 274; and left: x = -28, y = -32, z = 6, k = 21). CONCLUSIONS: The results in this study compare with those in previous studies and suggest that fMRI technology can provide an objective assessment of the pain experience.
U2 - 10.3171/2016.3.SPINE151230
DO - 10.3171/2016.3.SPINE151230
M3 - Article
C2 - 27203812
VL - 25
SP - 517
EP - 522
JO - Journal of Neurosurgery: Spine
JF - Journal of Neurosurgery: Spine
SN - 1547-5646
IS - 4
ER -