Functional imaging of the skin vasculature at the microscale in humans: Optical coherence tomography in diabetes and the impact of exercise training

This thesis developed a novel technique for assessment of microvessel structure and function in humans utilizing optical coherence tomography (OCT). This non-invasive technology is capable of directly visualizing and quantifying microvessels and, when combined with physiological testing, revealed abnormalities in the skin of diabetic subjects. It was also deployed to assess microvascular adaptation in response to exercise training. This thesis suggests that OCT is an accurate and robust technique capable of imaging and quantifying microvascular function and structure in humans, with promising future applications in human cardiovascular health and disease.