Fucoidans disrupt adherence of helicobacter pylori to AGS cells in vitro

Eng Chua, Phebe Verbrugghe, Tim Perkins, C.Y. Tay

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    © 2015 Eng-Guan Chua et al. Fucoidans are complex sulphated polysaccharides derived from abundant and edible marine algae. Helicobacter pylori is a stomach pathogen that persists in the hostile milieu of the human stomach unless treated with antibiotics. This study aims to provide preliminary data to determine, in vitro, if fucoidans can inhibit the growth of H. pylori and its ability to adhere to gastric epithelial cells (AGS). We analysed the activity of three different fucoidan preparations (Fucus A, Fucus B, and Undaria extracts). Bacterial growth was not arrested or inhibited by the fucoidan preparations supplemented into culture media. All fucoidans, when supplemented into tissue culture media at 1000 μg mL-1, were toxic to AGS cells and reduced the viable cell count significantly. Fucoidan preparations at 100 μg mL-1 were shown to significantly reduce the number of adherent H. pylori. These in vitro findings provide the basis for further studies on the clinical use of sulphated polysaccharides as complementary therapeutic agents.
    Original languageEnglish
    Article number120981
    Pages (from-to)1-6
    Number of pages6
    JournalEvidence-Based Complementary and Alternative Medicine
    Volume2015
    DOIs
    Publication statusPublished - 2015

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