From Structure to Function: Exploring the Importance of Non-canonical Secondary Structures in RNA

Uditi Bhatt

Research output: ThesisDoctoral Thesis

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Abstract

The structures of RNA are critical to its function, however are poorly characterised compared to their DNA counterparts. This PhD thesis investigates non-canonical RNA secondary structures as essential regulators of cellular processes. RNA G-quadruplexes (G4s) were identified transcriptome - wide and Z-RNAs discovered to form over i-motifs. We further identified a role of G4s in FUS protein binding to target RNAs, and paraspeckle formation. These results advance understanding of the structure-function relationship for RNAs, especially lncRNAs, and work towards understanding changes to the transcriptome and protein-RNA interactions in neurodegenerative diseases and cancer.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Smith, Nicole, Supervisor
  • Fox, Archa, Supervisor
  • Evans, Cameron, Supervisor
Thesis sponsors
Award date29 Jan 2024
DOIs
Publication statusUnpublished - 2023

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