From genetics to epigenetics: New insights into keloid scarring

Yongjing He, Zhenjun Deng, Mansour Alghamdi, Lechun Lu, Mark W. Fear, Li He

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars. Here we have reviewed three epigenetic mechanisms: DNA methylation, histone modification and the role of non-coding RNAs. We also review the evidence that these mechanisms may play a role in keloid formation - in future, it may be possible that epigenetic markers may be used instead of prognostic or diagnostic markers here. However, there is a significant amount of work required to increase our current understanding of the role of epigenetic modification in keloid disease.

Original languageEnglish
Article numbere12326
JournalCell Proliferation
Volume50
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

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