From ferrocene to fluorine-containing penta-substituted derivatives and all points in-between; or, how to increase the available chemical space

Mehdi Tazi, William Erb, Thierry Roisnel, Vincent Dorcet, Florence Mongin, Paul J. Low

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In spite of the growing interest in fluorine-containing compounds, and the improvements in materials, optical and biological properties that can arise from substitution of a phenyl ring by ferrocene within a molecular scaffold, synthetic strategies that allow the efficient preparation of fluoroferrocene derivatives are scarce. Following conversion of ferrocene to fluoroferrocene, we have developed routes to fluorine-containing di-, tri-, tetra- and penta-substituted ferrocene derivatives to extend the available chemical space. Our approach is based on the identification of suitable reagents and conditions to achieve fluorine-directed deprotometalation, and exploitation of the halogen 'dance' rearrangement in the ferrocene series.

Original languageEnglish
Pages (from-to)9352-9359
Number of pages8
JournalOrganic & Biomolecular Chemistry
Volume17
Issue number42
DOIs
Publication statusPublished - 30 Oct 2019

Fingerprint

Dive into the research topics of 'From ferrocene to fluorine-containing penta-substituted derivatives and all points in-between; or, how to increase the available chemical space'. Together they form a unique fingerprint.

Cite this