From beneath the skin to the airway wall: Understanding the pathological role of adipose tissue in comorbid asthma-obesity

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

This article provides a contemporary report on the role of adipose tissue in respiratory dysfunction. Adipose tissue is distributed throughout the body, accumulating beneath the skin (subcutaneous), around organs (visceral), and importantly in the context of respiratory disease, has recently been shown to accumulate within the airway wall: “airway-associated adipose tissue.” Excessive adipose tissue deposition compromises respiratory function and increases the severity of diseases such as asthma. The mechanisms of respiratory impairment are inflammatory, structural, and mechanical in nature, vary depending on the anatomical site of deposition and adipose tissue subtype, and likely contribute to different phenotypes of comorbid asthma-obesity. An understanding of adipose tissue-driven pathophysiology provides an opportunity for diagnostic advancement and patient-specific treatment. As an exemplar, the potential impact of airway-associated adipose tissue is highlighted, and how this may change the management of a patient with asthma who is also obese. © 2023 American Physiological Society. Compr Physiol 13:4321-4353, 2023.
Original languageEnglish
Pages (from-to)4321-4353
Number of pages33
JournalComprehensive Physiology
Volume13
Issue number1
DOIs
Publication statusPublished - 30 Jan 2023

Fingerprint

Dive into the research topics of 'From beneath the skin to the airway wall: Understanding the pathological role of adipose tissue in comorbid asthma-obesity'. Together they form a unique fingerprint.

Cite this