TY - JOUR
T1 - Friedel-crafts arylation of α-hydroxy ketones: Synthesis of 1,2,2,2-tetraarylethanones
AU - Kumar, A.
AU - Singh, T.V.
AU - Thomas, Sajesh
AU - Venugopalan, P.
PY - 2015
Y1 - 2015
N2 - © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Friedel-Crafts arylation of α-hydroxy ketones such as 2-hydroxy-1,2,2-triarylethanones has been achieved with a variety of arenes and heteroarenes in the presence of Lewis or Brønsted acids. Both sterically hindered and unhindered 1,2,2,2-tetrarylethanones are formed in good to excellent yields by using a stoichiometric amount of triflic acid. The intermediacy of an ?-keto carbenium ion has been proposed.
AB - © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Friedel-Crafts arylation of α-hydroxy ketones such as 2-hydroxy-1,2,2-triarylethanones has been achieved with a variety of arenes and heteroarenes in the presence of Lewis or Brønsted acids. Both sterically hindered and unhindered 1,2,2,2-tetrarylethanones are formed in good to excellent yields by using a stoichiometric amount of triflic acid. The intermediacy of an ?-keto carbenium ion has been proposed.
U2 - 10.1002/ejoc.201403438
DO - 10.1002/ejoc.201403438
M3 - Article
SN - 1434-193X
VL - 2015
SP - 1226
EP - 1234
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 6
ER -