Frequent questions and responses on the 2022 lipoprotein(a) consensus statement of the European Atherosclerosis Society

Florian Kronenberg, Samia Mora, Erik S.G. Stroes, Brian A. Ference, Benoit J. Arsenault, Lars Berglund, Marc R. Dweck, Marlys L. Koschinsky, Gilles Lambert, François Mach, Catherine J. McNeal, Patrick M. Moriarty, Pradeep Natarajan, Børge G. Nordestgaard, Klaus G. Parhofer, Salim S. Virani, Arnold von Eckardstein, Gerald F. Watts, Jane K. Stock, Kausik K. RayLale S. Tokgözoğlu, Alberico L. Catapano

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

In 2022, the European Atherosclerosis Society (EAS) published a new consensus statement on lipoprotein(a) [Lp(a)], summarizing current knowledge about its causal association with atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. One of the novelties of this statement is a new risk calculator showing how Lp(a) influences lifetime risk for ASCVD and that global risk may be underestimated substantially in individuals with high or very high Lp(a) concentration. The statement also provides practical advice on how knowledge about Lp(a) concentration can be used to modulate risk factor management, given that specific and highly effective mRNA-targeted Lp(a)-lowering therapies are still in clinical development. This advice counters the attitude: "Why should I measure Lp(a) if I can't lower it?". Subsequent to publication, questions have arisen relating to how the recommendations of this statement impact everyday clinical practice and ASCVD management. This review addresses 30 of the most frequently asked questions about Lp(a) epidemiology, its contribution to cardiovascular risk, Lp(a) measurement, risk factor management and existing therapeutic options.

Original languageEnglish
Pages (from-to)107-120
Number of pages14
JournalAtherosclerosis
Volume374
DOIs
Publication statusPublished - Jun 2023

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