Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas; Stephan Gadola; Ute Meier; Neil T. Young; Gillian Harcourt; Anastasios Karadimitris; Nikki Coumi; Dave Brown; Geoff Dusheiko; Vincenzo Cerundolo; Paul Klenerman

doi:10.1128/JVI.77.3.2251-2257.2003

Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas, Stephan Gadola, Ute Meier, Neil T. Young, Gillian Harcourt, Anastasios Karadimitris, Nikki Coumi, Dave Brown, Geoff Dusheiko, Vincenzo Cerundolo, Paul Klenerman

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/β11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Vα24/Vβ11 NKT cells found in blood, those in the liver appeared to be recently activated.

Original language	English
Pages (from-to)	2251-2257
Number of pages	7
Journal	Journal of Virology
Volume	77
Issue number	3
DOIs	https://doi.org/10.1128/JVI.77.3.2251-2257.2003
Publication status	Published - 1 Feb 2003
Externally published	Yes

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10.1128/JVI.77.3.2251-2257.2003

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title = "Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection",

abstract = "Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/β11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Vα24/Vβ11 NKT cells found in blood, those in the liver appeared to be recently activated.",

author = "Michaela Lucas and Stephan Gadola and Ute Meier and Young, {Neil T.} and Gillian Harcourt and Anastasios Karadimitris and Nikki Coumi and Dave Brown and Geoff Dusheiko and Vincenzo Cerundolo and Paul Klenerman",

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T1 - Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

AU - Lucas, Michaela

AU - Gadola, Stephan

AU - Meier, Ute

AU - Young, Neil T.

AU - Harcourt, Gillian

AU - Karadimitris, Anastasios

AU - Coumi, Nikki

AU - Brown, Dave

AU - Dusheiko, Geoff

AU - Cerundolo, Vincenzo

AU - Klenerman, Paul

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/β11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Vα24/Vβ11 NKT cells found in blood, those in the liver appeared to be recently activated.

AB - Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Vα24/β11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Vα24/Vβ11 NKT cells found in blood, those in the liver appeared to be recently activated.

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U2 - 10.1128/JVI.77.3.2251-2257.2003

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SN - 0022-538X

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JO - Journal of Virology

JF - Journal of Virology

IS - 3

ER -

Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

Abstract

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